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Publication
Evaluation of Morinda citrofolia chemopreventive effects against patulin
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Advisor(s)
Abstract(s)
Morinda citrofolia (noni), is a tropical plant that has been studied for its content of phenolic compounds, which display antioxidant properties. Although many authors have shown that fruit pulp is the part of noni plant richer in those compounds, all parts (leaves, rods and stem) are being used as traditional medicines in tropical countries. Patulin (PAT) is one of the most common mycotoxins, frequently found in spoiled fruits (apples), moldy feeds and stored cheese, representing a serious health concern because of its genotoxic, carcinogenic, neurotoxic and teratogenic effects that are mainly mediated by the formation of reactive oxygen species. Therefore, it is of utmost importance to identify bioactive natural compounds able to reduce the deleterious effects of patulin and other mycotoxins, in order to protect the human health. This is a particularly relevant concern in tropical regions where food contamination with mycotoxins has a strong negative impact on human health. On the other hand, ethyl methanesulfonate (EMS) is a model alkylating agent inducing mostly point mutations. This work intended to explore the chemopreventive properties of a noni fruit hexanic extract prepared in Brazil.
Description
Keywords
Bioactive compounds Chemoprevention Genotoxicidade Ambiental