Publication
In vitro acute toxicity of metal-based nanoparticles in human trophoblast BeWo b30 cells
| dc.contributor.author | Pires, J. | |
| dc.contributor.author | Moreira, L. | |
| dc.contributor.author | Teixeira, J.P. | |
| dc.contributor.author | Fraga, S. | |
| dc.date.accessioned | 2022-11-15T13:20:26Z | |
| dc.date.available | 2022-11-15T13:20:26Z | |
| dc.date.issued | 2021-09-24 | |
| dc.description | Abstract publicado em: Toxicol Lett. 2021 Sep;350 (Suppl):S110. doi: 10.1016/S0378-4274(21)00229-0 | pt_PT |
| dc.description.abstract | Metal nanoparticles (M-NP) are among the most widely used nanomaterials in consumer products available in the market. Thus, human exposure to these nanosized materials is increasing, which raises serious concerns regarding their environmental and human safety. Biological barriers are important lines of defence to xenobiotics, thus expected targets for M-NP. In this regard, special consideration must be given to the placenta that acts as barrier between maternal and the developing fetus. The present study aimed at evaluating in vitro toxicity of different M-NP in a human cell model of placental barrier: trophoblastic (BeWo clone b30) epithelial cells. BeWo b30 cells were exposed for 24 h to varied concentrations (0.8–48 µg/cm2) of M-NP of different chemical composition (Au, Ag and TiO2), primary size (10, 30 and 60 nm), capping (citrate and PEG) and crystal structure (rutile and anatase). | |
| dc.description.sponsorship | NanoBioBarriers (PTDC/MED-TOX/31162/2017) FCT | pt_PT |
| dc.description.sponsorship | This work was supported by the NanoBioBarriers project (PTDC/MEDTOX/31162/2017), co-financed by the Operational Program for Competitiveness and Internationalization (POCI) through European Region al Development Funds (FEDER/FNR) and through national funds by the Portuguese Foundation for Science and Technology (FCT). Thanks are also due to FCT/MCTES for the financial support to EPIUnit (UIDB/ 04750/2020). | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/8317 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0378427421005051 | pt_PT |
| dc.subject | Metal Nanoparticles | |
| dc.subject | Nanoparticles | |
| dc.subject | Genotoxicidade Ambiental | |
| dc.title | In vitro acute toxicity of metal-based nanoparticles in human trophoblast BeWo b30 cells | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-TOX%2F31162%2F2017/PT | |
| oaire.citation.conferencePlace | (online) | pt_PT |
| oaire.citation.issue | 350S | pt_PT |
| oaire.citation.startPage | S110 | pt_PT |
| oaire.citation.title | 56th Congress of the European Societies of Toxicology (EUROTOX), 'Toxicology of the next generation – Combined efforts in the quest for safer chemicals and medicines', 27 Sep-1 Oct 2021 | pt_PT |
| oaire.fundingStream | 9471 - RIDTI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Acesso de acordo com política editorial da revista. | pt_PT |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | 1370de00-d228-47a7-8aed-320831dc4dcd | |
| relation.isProjectOfPublication.latestForDiscovery | 1370de00-d228-47a7-8aed-320831dc4dcd |