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In vitro acute toxicity of metal-based nanoparticles in human trophoblast BeWo b30 cells
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Resumo(s)
Metal nanoparticles (M-NP) are among the most widely used nanomaterials in consumer products available in the market. Thus, human
exposure to these nanosized materials is increasing, which raises
serious concerns regarding their environmental and human safety.
Biological barriers are important lines of defence to xenobiotics, thus
expected targets for M-NP. In this regard, special consideration must
be given to the placenta that acts as barrier between maternal and
the developing fetus. The present study aimed at evaluating in vitro
toxicity of different M-NP in a human cell model of placental barrier:
trophoblastic (BeWo clone b30) epithelial cells. BeWo b30 cells were
exposed for 24 h to varied concentrations (0.8–48 µg/cm2) of M-NP
of different chemical composition (Au, Ag and TiO2), primary size (10,
30 and 60 nm), capping (citrate and PEG) and crystal structure (rutile
and anatase).
Descrição
Abstract publicado em: Toxicol Lett. 2021 Sep;350 (Suppl):S110. doi: 10.1016/S0378-4274(21)00229-0
Palavras-chave
Metal Nanoparticles Nanoparticles Genotoxicidade Ambiental