Repository logo
 
Publication

Molecular Epidemiology of Aspergillus collected from Cystic Fibrosis Patients

2014-10-30Journal article Restricted access
Simple item page
dc.contributor.authorSabino, R.
dc.contributor.authorFerreira, J.A.G.
dc.contributor.authorMoss, R.B.
dc.contributor.authorValente, J.
dc.contributor.authorVerissimo, C.
dc.contributor.authorCarolino, E.
dc.contributor.authorClemons, K.V.
dc.contributor.authorEverson, C.
dc.contributor.authorBanaei, N.
dc.contributor.authorPenner, J.
dc.contributor.authorStevens, D.A.
dc.date.accessioned2015-02-18T17:08:35Z
dc.date.available2015-02-18T17:08:35Z
dc.date.issued2014-10-30
dc.description.abstractBackground: Aspergillus respiratory infection is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function and allergic disease. Methods: Fifty-three Aspergillus isolates recovered fromCF patients were identified to species by Internal Transcribed Spacer Region (ITS), β-tubulin, and calmodulin sequencing. Results: Three species complexes (Terrei, Nigri, and Fumigati) were found. Identification to species level gave a single Aspergillus terreus sensu stricto, one Aspergillus niger sensu stricto and 51 Aspergillus fumigatus sensu stricto isolates. No cryptic species were found. Conclusions: To our knowledge, this is the first prospective study of Aspergillus species in CF using molecular methods. The paucity of non-A. fumigatus and of cryptic species of A. fumigatus suggests a special association of A. fumigatus sensu stricto with CF airways, indicating it likely displays unique characteristics making it suitable for chronic residence in that milieu. These findings could refine an epidemiologic and therapeutic approach geared to this pathogenpor
dc.description.sponsorshipRaquel Sabino was financially supported by a fellowship from Fundação para a Ciência e Tecnologia (FCT) Portugal (contract SFRH/BPD/72775/2010). This study was partially supported by a grant from the Child Health Research Institute, Stanford University, and a gift from Mr. John Flatley. José A.G. Ferreira was partially supported by a grant from the Brazilian National Council for Scientific and Technological Development (CNPq).por
dc.identifier.citationJ Cyst Fibros. 2015 Jul;14(4):474-81. doi: 10.1016/j.jcf.2014.10.005. Epub 2014 Oct 30.por
dc.identifier.doi10.1016/j.jcf.2014.10.005
dc.identifier.issn1569-1993
dc.identifier.urihttp://hdl.handle.net/10400.18/2899
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier/ European Cystic Fibrosis Societypor
dc.subjectCystic Fibrosispor
dc.subjectAspergilluspor
dc.subjectCryptic Speciespor
dc.subjectInfecções Sistémicas e Zoonosespor
dc.titleMolecular Epidemiology of Aspergillus collected from Cystic Fibrosis Patientspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Cystic Fibrosispor
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Final published cystic fibrosis paper.pdf
Size:
209.22 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DDI - Artigos em revistas internacionais