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Publicação
Molecular Epidemiology of Aspergillus collected from Cystic Fibrosis Patients
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Orientador(es)
Resumo(s)
Background: Aspergillus respiratory infection is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function
and allergic disease.
Methods: Fifty-three Aspergillus isolates recovered fromCF patients were identified to species by Internal Transcribed Spacer Region (ITS), β-tubulin,
and calmodulin sequencing.
Results: Three species complexes (Terrei, Nigri, and Fumigati) were found. Identification to species level gave a single Aspergillus terreus sensu
stricto, one Aspergillus niger sensu stricto and 51 Aspergillus fumigatus sensu stricto isolates. No cryptic species were found.
Conclusions: To our knowledge, this is the first prospective study of Aspergillus species in CF using molecular methods. The paucity of non-A.
fumigatus and of cryptic species of A. fumigatus suggests a special association of A. fumigatus sensu stricto with CF airways, indicating it likely
displays unique characteristics making it suitable for chronic residence in that milieu. These findings could refine an epidemiologic and therapeutic
approach geared to this pathogen
Descrição
Palavras-chave
Cystic Fibrosis Aspergillus Cryptic Species Infecções Sistémicas e Zoonoses
Contexto Educativo
Citação
J Cyst Fibros. 2015 Jul;14(4):474-81. doi: 10.1016/j.jcf.2014.10.005. Epub 2014 Oct 30.
Editora
Elsevier/ European Cystic Fibrosis Society