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Linear Regression Analysis of Harmonized IgG Antibody Levels Against the SARS-CoV-2 Spike Protein: A Cohort Study in Healthcare Workers

2025-10Documento de conferência Acesso aberto
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dc.contributor.authorSaraiva, Ana Leonor
dc.contributor.authorAfreixo, Vera
dc.contributor.authorMachado, Ausenda
dc.contributor.authorGaio, Vânia
dc.date.accessioned2026-03-03T17:52:12Z
dc.date.available2026-03-03T17:52:12Z
dc.date.issued2025-10
dc.description.abstractThe emergence of COVID-19 in 2019 led to the rapid development of vaccines and diagnostic tests. To assess antibody responses in healthcare workers (HCWs), a cohort study was conducted between 2021 and 2022 across three Portuguese hospitals. Antibody levels were measured at six time points: prevaccination, post-vaccination, and at 3, 6, and 12 months after the vaccination, as well as after the booster dose. Each hospital used a different assay: Abbott’s CMIA, Roche’s Elecsys® ECLIA, and Siemens’ ADVIA Centaur®, posing challenges for data comparability. The study aimed to harmonize serological data across these hospitals and to model antibody increases and decreases over time using linear regression. To ensure adequate conversion of antibody titers from different laboratory methods, quantile harmonization, and Deming regression were applied. After harmonization, three linear regressions were fitted: one for the increase between prevaccination and post-vaccination, another for the decrease between post-accination and 12 months after vaccination, and finally, one for the increase between 12 months after vaccination and after the booster dose. Models included variables such as prior infection, age, hospital, smoking status, contact with COVID-19 patients, and chronic conditions. In the phase-specific analysis, in addition to variations between hospitals in the regression of the last increase after the booster dose, it was observed that individuals over 50 years of age exhibited a superior immune response (811 550; IC 95%: 598 774, 1 024 327; p < 0.001). This higher percentage increase may be explained by initially lower levels, unlike younger individuals who had higher titers.eng
dc.description.sponsorshipThe data of the study were originally collected as part of the project ‘Developing an infrastructure and performing vaccine effectiveness studies for COVID- 19 vaccine in the EU/EEA’ (Contract ECD.11486 Lot3 (HCW) and amendment Nº ECD.11486), and the Enhanced laboratory support to perform assessment of vaccine effectiveness against SARS- CoV- 2 infection (ECD.12175) and the ‘Vaccine Effectiveness, Burden and Impact Studies (VEBIS) of COVID- 19 and Influenza’, funded by the European Centre for Disease Prevention and Control through a service contract with Epiconcept (ECD.12609)
dc.identifier.urihttp://hdl.handle.net/10400.18/11069
dc.language.isoeng
dc.peerreviewedn/a
dc.relationVEBIS Lot2
dc.rights.uriN/A
dc.subjectSARS-CoV-2
dc.subjectIgG antibody
dc.subjectHealthcare Workers
dc.subjectHarmonization
dc.subjectVEBIS
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectEstados de Saúde e de Doença
dc.subjectInfecções Respiratórias
dc.titleLinear Regression Analysis of Harmonized IgG Antibody Levels Against the SARS-CoV-2 Spike Protein: A Cohort Study in Healthcare Workerseng
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferenceDate2025-10
oaire.citation.conferencePlaceFaro, Portugal
oaire.citation.titleXXVII Congresso da Sociedade Portuguesa de Estatística, 22-25 outubro 2025
oaire.versionhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43
person.familyNameMachado
person.familyNameGaio
person.givenNameAusenda
person.givenNameVânia
person.identifier.ciencia-id1217-6076-5D88
person.identifier.ciencia-idA71A-17AF-30C7
person.identifier.orcid0000-0002-1849-1499
person.identifier.orcid0000-0001-7626-4991
person.identifier.scopus-author-id56080468200
relation.isAuthorOfPublication544ad266-0c22-4a50-9ebc-86acc08d6666
relation.isAuthorOfPublication59791814-187c-4b34-b3a2-6ad67a213814
relation.isAuthorOfPublication.latestForDiscovery544ad266-0c22-4a50-9ebc-86acc08d6666

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