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Tracking Mycotoxin Exposure in Portugal: New Insights and Key Determinants

2025-11-21Documento de conferência Acesso restrito
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datacite.subject.fosCiências Naturais
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorNamorado, Sónia
dc.contributor.authorMaris, Elias
dc.contributor.authorChen, A.
dc.contributor.authorPero-Gascon, Roger
dc.contributor.authorde Boevre, Marthe
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorSilva, Maria João
dc.contributor.authorAlvito, Paula
dc.contributor.editor.
dc.date.accessioned2026-03-03T18:39:39Z
dc.date.available2026-03-03T18:39:39Z
dc.date.issued2025-11-21
dc.description.abstractHuman biomonitoring (HBM) is a vital tool for assessing exposure to environmental chemicals. Mycotoxins have been associated with various adverse health effects, including estrogenic, immunotoxic, nephrotoxic, and teratogenic outcomes. In this presentation an overview of two recent HBM studies on multiple mycotoxins exposure biomarkers conducted in Portugal will be given. The first study analyzed 37 mycotoxin biomarkers in urine samples from 94 adult participants (48.4 ± 15.2 years), as part of the National Food, Nutrition, and Physical Activity Survey (2015–2016). Six different mycotoxins -DON, ZEN, AOH, OTA, FB1, and CIT- was confirmed through the quantification of 12 urinary biomarkers in paired 24 h and first-morning urine samples. DON and its metabolites were among the most frequently detected biomarkers and AOH was identified for the first time in urine samples from a European population. Associations between urinary mycotoxin biomarkers and consumption of specific food items were also observed. More recently, a subset of 295 first-morning urine samples from adults (28–39 years) was collected between 2019-2020, as part of a cross-sectional study embedded within the Portuguese National Health Examination Survey (INSEF). These samples were analyzed using a newly optimized and validated LC-MS/MS method capable of detecting 40 mycotoxins and/or their metabolites in urine. DON and tenuazonic acid were the most frequently detected, with detection rates of 85% and 96%, respectively. Further investigations into key exposure determinants—including dietary habits, demographic factors, and geographical variations—are ongoing and will be presented. Altogether, these findings highlight the importance of continued surveillance and the integration of HBM into national food safety and public health strategies.eng
dc.description.sponsorshipThe INSEF-ExpoQuim study is supported under the HBM4EU project co-funded by Horizon 2020 (No. 733032). Thanks also to CESAM, ToxOmics and CHRC by FCT/MCTES through national funds (UIDP/50017/2020, UID/50006/2020+LA/P/0094/2020(doi.org/10.54499/LA/P/0094/2020), UIDP/00009/2020, UIDB/00009/2020, UIDP/04923/2020, UIDB/04923/2020). E.M is supported by an iBOF project (No. 01IB1320); A. Chen by an FWO PhD fellowship (11A0725N); R. P-G by an FWO postdoctoral fellowship (12D4423N) and M. De Boevre by the European Research Council (No. 946192, HUMYCO).
dc.identifier.urihttp://hdl.handle.net/10400.18/11088
dc.language.isoeng
dc.peerreviewedn/a
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relationComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
dc.relationUIDB/04923/2020
dc.relationUID/50006/2020
dc.rights.uriN/A
dc.subjectToxicologia
dc.subjectBiomonitorizaçao Humana
dc.subjectAvaliação de Risco
dc.subjectMicotoxinas
dc.titleTracking Mycotoxin Exposure in Portugal: New Insights and Key Determinantseng
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUIDP/50017/2020
oaire.awardNumberLA/P/0094/2020
oaire.awardNumberUIDP/00009/2020
oaire.awardNumberUIDB/00009/2020
oaire.awardNumberUIDP/04923/2020
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04923%2F2020/PT
oaire.citation.conferenceDate2025-11-21
oaire.citation.conferencePlaceValencia, Spain
oaire.citation.titleIV International Workshop on Alternative methods for the determination of toxic effects and risk assessment of contaminants and mixtures entitled "Food safety tools for mycotoxins and acrylamide risk exposure assessment", RiskTox Group, 21 November 2025
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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