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Nonsense-mediated mRNA decay (NMD): a bifunctional mechanism in human physiology and disease

2020-10-14Outro Acesso aberto
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dc.contributor.authorFernandes, Rafael
dc.contributor.authorRomão, Luísa
dc.date.accessioned2021-05-12T11:31:16Z
dc.date.available2021-05-12T11:31:16Z
dc.date.issued2020-10-14
dc.descriptionPublication: Fernandes R, Nogueira G, da Costa PJ, Pinto F, Romão L. Nonsense-Mediated mRNA Decay in Development, Stress and Cancer. Adv Exp Med Biol. 2019;1157:41-83. doi: 10.1007/978-3-030-19966-1_3pt_PT
dc.descriptionAtlas of Science is established to help scientists share, and to bring science to the broader audience. The publication of Layman summaries by academic researchers and access to these summaries for the general public will always be free of charge.pt_PT
dc.description.abstractProteins are the working-units of the cell, which are encoded by thousands of genes that pass their information into an intermediate molecule, the messenger RNA (mRNA). For this flow of information – from genes to RNA (transcription), and then into proteins (translation) – to occur properly, the cell has developed several check points and mechanisms that limit the occurrence and transmission of errors. Some of these mechanisms act at the mRNA level to ensure that the information transcribed from a gene will yield a proper functional protein after mRNA translation. Nonsense-mediated mRNA decay (NMD) is a translation-dependent surveillance mechanism that rapidly degrades transcripts with premature stop codons (PTCs), like the ones bearing nonsense mutations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7738
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAoS Nordic ABpt_PT
dc.relation.publisherversionhttps://atlasofscience.org/nonsense-mediated-mrna-decay-nmd-a-bifunctional-mechanism-in-human-physiology-and-disease/pt_PT
dc.subjectNonsense-mediated mRNA Decaypt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectHuman Diseasept_PT
dc.subjectIntegrated Stress Responsept_PT
dc.subjectTumorigenesispt_PT
dc.subjectUnfolded Protein Responsept_PT
dc.subjectmRNA Surveillancept_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.subjectDoenças Genéticapt_PT
dc.titleNonsense-mediated mRNA decay (NMD): a bifunctional mechanism in human physiology and diseasept_PT
dc.typeother
dspace.entity.typePublication
oaire.citation.titleAtlas of Sciencept_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeotherpt_PT

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