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Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface
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Orientador(es)
Resumo(s)
Ceruloplasmin is a positive acute-phase protein with both anti- and pro-oxidant activities, thus having still unclear physiological functions in inflammatory processes. Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux. Ceruloplasmin can be expressed as a secreted or as a membrane glycosylphosphatidylinositol-anchored protein (GPI-ceruloplasmin), this latter one being reported as expressed mostly in the brain.
Descrição
Palavras-chave
Determinantes Imunológicos em Doenças Crónicas GPI-ceruloplasmin Ferroportin Lipid raft Immune cells Hepatocytes Iron metabolism Doenças Genéticas
Contexto Educativo
Citação
Blood Cells Mol Dis. 2011 Dec 15. [Epub ahead of print]
Editora
Elsevier