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Publication
Primeiro estudo em Portugal sobre a identificação dos genótipos do vírus do papiloma humano (HPV) numa população feminina vacinada com atividade sexual ativa
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Advisor(s)
Abstract(s)
A infeção por HPV é responsável por 99,7% dos casos de cancro de colo
do útero a nível mundial. De modo a prevenir e a minimizar o impacto da
infeção por HPV na saúde das mulheres foram desenvolvidas vacinas. A
vacina tetravalente está incluída no Plano Nacional de Vacinação (PNV)
desde 2008. Com o objetivo de se conhecer a distribuição dos genótipos
HPV estudaram-se 152 amostras clínicas de mulheres jovens vacinas
com atividade sexual ativa. As amostras clínicas foram colhidas
por cytobrush, procedeu-se à deteção e tipificação do HPV pela técnica
de microarrays. Das mulheres estudadas, 28,3% apresentaram infeção
por genótipos HPV, dos quais 58,1% corresponderam a genótipos
de alto risco, sendo mais frequente o HPV 51 (15,2%) seguido do HPV 59
e HPV 58 com 7,6% e 6,1%, respetivamente. Foram também detetados
dois casos de infeção por HPV 16, que é um dos genótipos incluído na
vacina. Genótipos de baixo risco foram detetados em 25,6% de infeções,
sendo o HPV42 o mais frequente com 9,1% dos casos. A história vacinal
demonstrou que 83,1% das mulheres foram vacinadas ao abrigo do PNV
e iniciaram atividade sexual após administração da vacina, e que 53,6%
das mulheres vacinadas fora do PNV iniciaram atividade sexual antes da
administração da vacina. Portugal apresenta uma taxa de cobertura vacinal
elevada. Estes primeiros resultados reforçam a importância da administração
da vacina antes do início da atividade sexual e de se manter
o rastreio do cancro do colo do útero.
Infection with HPV is responsible for 99.7% cases of cer vical cancer worldwide, to prevent and minimize the impact on women´s health have been developed vaccines against HPV infection. The tetravalent vaccine is included in the National Immunization Program (PNV) since 2008. With the aim to know the distribution of HPV genotypes, 152 clinical samples of young women who have star ted sexual life were studied. Clinical samples were collected by cy tobrush, HPV detection and typing was per formed by the microarray methodology. Of the women studied, 28.3% presented infection for HPV genotypes, 58.1% corresponding to the high-risk genotypes, with HPV 51 (15.2%) being more frequent followed by HPV 59 and HPV 58 with 7.6% and 6.1%, respectively. Two cases of HPV 16 infection were also detected, genotype included in the vaccine. Low-risk genotypes were detected in 25.6% of the infections with HPV 42 being the most frequent in 9.1% of the cases. Vaccine histor y showed 83.1% of women were vaccinated in the current immunization program and star ted sexual activity af ter HPV vaccine administration, and 53.6% of women vaccinated outside current immunization program star ted sexual activity before to vaccine administration. Por tugal has a high vaccination coverage rate. However, these early results reinforce the impor tance of administration the vaccine before the onset of sexual activity and to keep tracking of cer vical cancer.
Infection with HPV is responsible for 99.7% cases of cer vical cancer worldwide, to prevent and minimize the impact on women´s health have been developed vaccines against HPV infection. The tetravalent vaccine is included in the National Immunization Program (PNV) since 2008. With the aim to know the distribution of HPV genotypes, 152 clinical samples of young women who have star ted sexual life were studied. Clinical samples were collected by cy tobrush, HPV detection and typing was per formed by the microarray methodology. Of the women studied, 28.3% presented infection for HPV genotypes, 58.1% corresponding to the high-risk genotypes, with HPV 51 (15.2%) being more frequent followed by HPV 59 and HPV 58 with 7.6% and 6.1%, respectively. Two cases of HPV 16 infection were also detected, genotype included in the vaccine. Low-risk genotypes were detected in 25.6% of the infections with HPV 42 being the most frequent in 9.1% of the cases. Vaccine histor y showed 83.1% of women were vaccinated in the current immunization program and star ted sexual activity af ter HPV vaccine administration, and 53.6% of women vaccinated outside current immunization program star ted sexual activity before to vaccine administration. Por tugal has a high vaccination coverage rate. However, these early results reinforce the impor tance of administration the vaccine before the onset of sexual activity and to keep tracking of cer vical cancer.
Description
Keywords
Vírus do Papiloma Humano HPV Infecções Sexualmente Transmissíveis Vacinas População Feminina Cancro do Colo Cancro do Útero Doenças Infecciosas Saúde Pública Portugal
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2017 janeiro-abril;6(18):4-9
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP