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Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci

2017-05-08Conference object Restricted access
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dc.contributor.authorBarros, Patrícia
dc.contributor.authorAmaral, Andreia
dc.contributor.authorAbrantes, Leonor
dc.contributor.authorOliveira, Tiago
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.contributor.authorJordan, Peter
dc.contributor.authorGama-Carvalho, Margarida
dc.contributor.authorMatos, Paulo
dc.date.accessioned2018-03-05T18:21:45Z
dc.date.available2018-12-31T01:30:12Z
dc.date.issued2017-05-08
dc.description.abstractColorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.pt_PT
dc.description.sponsorshipCenter grant UID/MULTI/04046/2013 to BioISI, IF2012 Development grant and PTDC/SAU/GMG/119586/2010 to PM, FCT fellowship SFRH/BPD/94322/2013 to PB and EMBO long-term fellowship ALT-33-2010 and FCT fellowship SFRH/BPD/65976/2009 to AJA.pt_PT
dc.description.versioninfo:eu-repo/semantics/submittedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5193
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectCancro Coloretalpt_PT
dc.subjectRAC1pt_PT
dc.subjectReparação do DNApt_PT
dc.titleStimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed locipt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-GMG%2F119586%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F94322%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F65976%2F2009/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title2º Dia do Jovem Investigador do Instituto Nacional de Saúde Doutor Ricardo Jorge, 8 maio 2017pt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctDados não publicadospt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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