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Publication
Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci
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| 1.52 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found
overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to
unfavourable clinical prognosis, often resulting from chemoresistance.
Description
Keywords
Vias de Transdução de Sinal e Patologias Associadas Cancro Coloretal RAC1 Reparação do DNA