Regulation of glucose transporters by protein kinases in cancer cells

Henriques, Andreia F.; Matos, Paulo; Jordan, Peter

http://hdl.handle.net/10400.18/5394

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
EMJ oncology 2017_AR Andreia.pdf		2.08 MB	Adobe PDF	Download

Send Feedback

Authors

Henriques, Andreia F.

Matos, Paulo

Jordan, Peter

Abstract(s)

Reprogramming of energy metabolism is one of the hallmarks of cancer, since tumour cells need to fuel their high proliferation rates. Warburg et al. first observed that cancer cells largely limit their method of energy production to glycolysis only. In order to compensate for lower ATP yields, cancer cells often upregulate expression of glucose transporters, typically GLUT1, which substantially increases extracellular glucose import into the cytoplasm.

Keywords

WNK Protein Kinases Colorectal Cancer Tumor Cells WNK Proteina Cinases Transporte de Glucose Vias de Transdução de Sinal e Patologias Associadas Cancro Coloretal