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SARS-CoV-2 Seroprevalence among hospital healthcare workers in comparison with the general population, 2021-2022

2025-09Documento de conferência Acesso aberto
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dc.contributor.authorGaio, Vânia
dc.contributor.authorAmaral, Palmira
dc.contributor.authorSantos, Ana João
dc.contributor.authorHenriques, Camila
dc.contributor.authorValadas Henriques, Camila
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorMachado, Ausenda
dc.date.accessioned2026-03-03T16:52:00Z
dc.date.available2026-03-03T16:52:00Z
dc.date.issued2025-09
dc.descriptionGac Sanit. 2025;39(S2):647. doi: 10.1016/S0213-9111(25)00756-3
dc.description.abstractBackground/Objectives: Healthcare workers (HCWs) are essential as frontline responders during infectious disease health emergencies. Protecting them is crucial to ensure their health, maintain continuous patient care, and prevent transmission to patients. This study aimed to estimate the SARS-CoV-2 seroprevalence trend among HCWs from a Portuguese hospital cohort between May 2021 and June 2022. It also aimed to compare it with the seroprevalence trend in the general population aged 40-49. Additionally, the characterization of HCWs with seroconversion was performed based on their positivity for anti-nucleocapsid (Anti-N) IgG antibodies. Methods: As part of a vaccine effectiveness study, HCWs were screened for anti-RBD/Spike IgG antibodies against SARS-CoV-2 in three time points: May–July 2021, September-November 2021, and May–June 2022. At the last moment, Anti-N IgG antibodies were also assessed. To compare with data on the general population, we used results from three National Serological Surveys (NSS) phases (February–March 2021, September–November 2021, and April–June 2022) focusing on the 40–49 age group, the most representative among HCW. HCW characteristics were compared according to anti-N IgG seropositivity using the Chi-square and Mann-Whitney tests, assuming a significance level of 0.05. Results: HCWs screening at the 3 moments included 909, 474, and 67 individuals respectively with SARS-CoV-2 seroprevalence was 86%, 90%, and 100%, respectively. These seroprevalences were similar to those found in the Portuguese general population, except for the first period (86% versus 18.8% in the general population, age group 40-49 years). At the last moment, the post-infection seroprevalence (anti-N IgG antibodies) was higher among HCWs than in the general population (41% versus 27%). A lower age and direct contact with COVID-19 patients were associated with anti-N IgG antibody positivity. Conclusions/Recommendations: The increasing trend of seroprevalence among HCWs follows the same trend in the general population. Although the time points differ, in the first moment, higher SARS-CoV-2 seroprevalence was probably linked to priority vaccine uptake. In the third moment, the higher post-infection seroprevalence among HCWs suggests a raised exposure and infection incidence in HCWs following the Omicron wave. Given the decline in COVID-19 vaccination coverage among HCWs in the post-pandemic period, ongoing monitoring of seroprevalence and COVID-19 infection rates in this group remains crucial.eng
dc.identifier.urihttp://hdl.handle.net/10400.18/11056
dc.language.isopor
dc.peerreviewedn/a
dc.relation.hasversionhttps://gacetasanitaria.org/en-707-sars-cov-2-seroprevalence-among-articulo-S0213911125007563
dc.rights.uriN/A
dc.subjectHealthcare Workers
dc.subjectSeroprevalence
dc.subjectSARS-CoV-2
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectEstados de Saúde e de Doença
dc.subjectInfecções Respiratórias
dc.titleSARS-CoV-2 Seroprevalence among hospital healthcare workers in comparison with the general population, 2021-2022eng
dc.title.alternativeSeroprevalência de SARS-CoV-2 em profissionais de saúde de hospitais em comparação com a população geral, 2021-2022por
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferenceDate2025-09-06
oaire.citation.conferencePlaceLas Palmas, Gran Canaria, Spain
oaire.citation.titleXX Congresso da Associação Portuguesa de Epidemiologia (APE)/XLIII Reunión anual de la Sociedad Española de Epidemiología (SEE), 2-5 September 2025
oaire.versionhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43
person.familyNameGaio
person.familyNameValadas Henriques
person.givenNameVânia
person.givenNameCamila
person.identifier.ciencia-idA71A-17AF-30C7
person.identifier.ciencia-id851F-4E5E-D0AD
person.identifier.orcid0000-0001-7626-4991
person.identifier.orcid0000-0002-3654-4929
person.identifier.scopus-author-id56080468200
relation.isAuthorOfPublication59791814-187c-4b34-b3a2-6ad67a213814
relation.isAuthorOfPublication6fe03523-acfc-4a28-ba2d-ab0d9b911d1e
relation.isAuthorOfPublication.latestForDiscovery6fe03523-acfc-4a28-ba2d-ab0d9b911d1e

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