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Oral Exposure to Titanium dioxide nanoparticles: a Systematic Literature Review as a tool to develop Adverse Outcome Pathway landscapes and supporting in vitro assays

2022-11-16Lecture Restricted access
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dc.contributor.authorRolo, Dora
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2022-11-28T14:49:40Z
dc.date.available2022-11-28T14:49:40Z
dc.date.issued2022-11-16
dc.description.abstractDespite being considered key enabling technologies, the exponential use of nanoparticles in food technology leads to concerns about adverse health outcomes upon ingestion. The use of Titanium dioxide nanoparticles (TiO2-NPs) as a food additive was considered no longer safe by the European Food Safety Authority (EFSA) in 2022, and the European Commission announced the decision to ban its use. Nevertheless, other products containing TiO2-NPs, such as pharmaceuticals, personal hygiene, or cosmetics, that are not covered in the food regulation, may lead to ingestion of TiO2-NPs. In this regard, further research is needed. A valuable tool is the establishment of Adverse Outcome Pathways (AOPs) landscapes, which contributes to support risk assessment and may drive policy decisions. AOPs describes a sequence of causally linked events at different levels of biological organization leading to adverse health effects. Our main goal was to further understand the molecular and cellular mechanisms, triggered after the ingestion of TiO2-NPs. A systematic literature review was performed, integrating information produced on this topic and provide data for a standardized assessment of the evidence. AOP landscapes were proposed in order to identify mechanisms that mediate adverse outcomes, and additional in vitro assays were performed. Our in vitro findings suggest that part of the ingested TiO2-NPs can be transcytosed through colonic epithelia without disrupting intestinal barrier integrity. These results are consistent with our AOPs proposal where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. Based on a mechanistic reasoning, this study contributes to increase the understanding of ingested TiO2-NPs kinetics, their bioavailabity to induce systemic effects crossing the intestinal barrier and potential fate in Humans. Overall, the findings further support a limitation of the use of TiO2-NPs in food, as announced by EFSA.pt_PT
dc.description.sponsorshipFunded by FCT/MCTES through the projects: PTDC/SAU-PUB/29481/2017, UIDB/00009/2020; UIDP/00009/2020;UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020; CEECIND/03143/2017 (LG), 2020.07168.BD (NV).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8343
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relationResearch Institute for Medicines
dc.relationNot Available
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationToxicological profile of cellulose nanomaterials in human gastrointestinal cells
dc.subjectIngested Nanomaterialspt_PT
dc.subjectAdverse Outcome Pathwayspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOral Exposure to Titanium dioxide nanoparticles: a Systematic Literature Review as a tool to develop Adverse Outcome Pathway landscapes and supporting in vitro assayspt_PT
dc.typelecture
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNot Available
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleToxicological profile of cellulose nanomaterials in human gastrointestinal cells
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03143%2F2017%2FCP1476%2FCT0005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.07168.BD/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleSeminários do DGH, INSA, 16 novembro 2022pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameLouro
person.givenNameMaria Joao
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typelecturept_PT
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