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Biological effects of ingested nanomaterials and potential adverse outcomes for human health

2020-11-03Documento de conferência Acesso restrito
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dc.contributor.authorVieira, Adriana
dc.contributor.authorGramacho, Ana Catarina
dc.contributor.authorRolo, Dora
dc.contributor.authorVital, Nádia
dc.contributor.authorPereira, Joana
dc.contributor.authorMatos, Paulo
dc.contributor.authorJordan, Peter
dc.contributor.authorMartins, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorBettencourt, Ana F.
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2021-03-13T14:53:06Z
dc.date.available2021-03-13T14:53:06Z
dc.date.issued2020-11-03
dc.description.abstractThe technology based on manufactured nanomaterials (NMs) has been pointed as key enabling technology, due to its potential to improve many products and processes, namely in agriculture, food and feed industry, leading to an exponential growth. Many products, already available, have NMs, such titanium dioxide NMs used as food additives, and many others are in development. Oral exposure may occur either directly, through the consumption of products/pharmaceuticals containing NMs, or indirectly, through the ingestion of foods contaminated with NMs released from food-contact materials or even through concentration in the food chain due to environmental accumulation. Therefore, the gastrointestinal tract appears to be a probable route of exposure to NMs and may lead to systemic exposure if the body barriers are surpassed. One major concern for public health is that NMs may produce biological effects, such as genotoxicity that are associated with increased risk of cancer. Although NMs have been extensively investigated in recent years, the studies have generated contradictory results, possibly due to differences in the physicochemical properties of the NMs studied and to other variables in the test systems. This work aimed to investigate the nano-bio interactions of titanium dioxide NMs, at cellular and molecular level, in the context of intestinal tract and digestion processes, to better understand their potential adverse impacts on human health. The results of the NMs uptake by intestinal cells, as well as their cytotoxic and genotoxic effects will be presented. This nanotoxicology approach may be incorporated at early-stage in the development of new NMs for food industry, in a “safe-by-design” approach that will enable safety to keep pace with innovation.pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES through national funds (PIDDAC), PTDC/SAUPUB/29481/2017 and co-funded by UIDP/00009/2020 (Centre for Toxicogenomics and Human Health – ToxOmics, FCT), iMed.ULisboa (Pest-UID/DTP/04138/2018) and CESAM (UID/AMB/50017/2019).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7442
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.relation.publisherversionhttps://www.encontrociencia.pt/comunicacoes/3152_comunicacao_20201101203333_Henriqueta_Louro_2020_Encontro_Ciencia.pdfpt_PT
dc.subjectNanomaterialspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectIngested Nanomaterialspt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleBiological effects of ingested nanomaterials and potential adverse outcomes for human healthpt_PT
dc.title.alternativeEfeitos biológicos dos nanomateriais ingeridos e potenciais impactos para a saúde humana
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleEncontro com a Ciência e Tecnologia em Portugal, 3-4 november 2020pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameSilva
person.familyNameLouro
person.givenNameMaria Joao
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublication10a38358-808e-4126-a323-58973bebbcce
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