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Advisor(s)
Abstract(s)
An exponential increase in products containing titanium dioxide nanomaterials (TiO2), in
agriculture, food and feed industry, lead to increased oral exposure to these nanomaterials
(NMs). Thus, the gastrointestinal tract (GIT) emerges as a possible route of exposure that
may drive systemic exposure, if the intestinal barrier is surpassed. NMs have been suggested
to produce adverse outcomes, such as genotoxic effects, that are associated with increased
risk of cancer, leading to a concern for public health. However, to date, the differences in the
physicochemical characteristics of the NMs studied and other variables in the test systems
have generated contradictory results in the literature.
Processes like human digestion may change the NMs characteristics, inducing
unexpected toxic effects in the intestine. Using TiO2 as case-study, this chapter provides a review of the works addressing the interactions of NMs with biological systems in the context of intestinal tract and digestion processes, at cellular and molecular level. The knowledge gaps identified suggest that the incorporation of a simulated digestion process for in vitro studies has the potential to improve the model for elucidating key events elicited by these NMs, advancing the nanosafety studies towards the development of an adverse outcome
pathway for intestinal effects.
Description
Keywords
Titanium Dioxide Ingestion Nanomaterials Nanotoxicology Intestinal Cells Environmental Genotoxicity Genotoxicidade Ambiental
Pedagogical Context
Citation
In: Louro H, Silva MJ (eds). Nanotoxicology in Safety Assessment of Nanomaterials. Springer, Cham., 2022, pp. 225-57. (Advances in Experimental Medicine and Biology;1357). https://doi.org/10.1007/978-3-030-88071-2_14
Publisher
Springer