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Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nanomaterials

2022Book part Restricted access
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dc.contributor.authorVieira, Adriana
dc.contributor.authorGramacho, Ana
dc.contributor.authorRolo, Dora
dc.contributor.authorVital, Nádia
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2022-11-29T11:29:19Z
dc.date.available2022-11-29T11:29:19Z
dc.date.issued2022
dc.description.abstractAn exponential increase in products containing titanium dioxide nanomaterials (TiO2), in agriculture, food and feed industry, lead to increased oral exposure to these nanomaterials (NMs). Thus, the gastrointestinal tract (GIT) emerges as a possible route of exposure that may drive systemic exposure, if the intestinal barrier is surpassed. NMs have been suggested to produce adverse outcomes, such as genotoxic effects, that are associated with increased risk of cancer, leading to a concern for public health. However, to date, the differences in the physicochemical characteristics of the NMs studied and other variables in the test systems have generated contradictory results in the literature. Processes like human digestion may change the NMs characteristics, inducing unexpected toxic effects in the intestine. Using TiO2 as case-study, this chapter provides a review of the works addressing the interactions of NMs with biological systems in the context of intestinal tract and digestion processes, at cellular and molecular level. The knowledge gaps identified suggest that the incorporation of a simulated digestion process for in vitro studies has the potential to improve the model for elucidating key events elicited by these NMs, advancing the nanosafety studies towards the development of an adverse outcome pathway for intestinal effects.pt_PT
dc.description.sponsorshipThis work was funded by national funds through the FCT - Foundation for Science and Technology, I.P., under the project INGESTnano- PTDC/ SAU-PUB/29481/2017. Research co-funded by European Union Seventh Framework Programme (FP7/ 2007e2013) under the project NANoREG (A common European approach to the regulatory testing of nanomaterials), grant agreement 310584 and by UIDB/00009/2020; UIDP/00009/2020 (Centre for Toxicogenomics and Human Health – ToxOmics, Foundation for Science and Technology). NV holds a FCT PhD Scholarship grant (2020.07168.BD).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIn: Louro H, Silva MJ (eds). Nanotoxicology in Safety Assessment of Nanomaterials. Springer, Cham., 2022, pp. 225-57. (Advances in Experimental Medicine and Biology;1357). https://doi.org/10.1007/978-3-030-88071-2_14pt_PT
dc.identifier.doi10.1007/978-3-030-88071-2_10pt_PT
dc.identifier.eissn2214-8019
dc.identifier.issn0065-2598
dc.identifier.urihttp://hdl.handle.net/10400.18/8364
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationA common European approach to the regulatory testing of nanomaterials
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relationToxicological profile of cellulose nanomaterials in human gastrointestinal cells
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007/978-3-030-88071-2_10#citeaspt_PT
dc.subjectTitanium Dioxidept_PT
dc.subjectIngestionpt_PT
dc.subjectNanomaterialspt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectIntestinal Cellspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleCellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nanomaterialspt_PT
dc.title.alternativeNanotoxicology in Safety Assessment of Nanomaterialspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleA common European approach to the regulatory testing of nanomaterials
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleToxicological profile of cellulose nanomaterials in human gastrointestinal cells
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/310584/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.07168.BD/PT
oaire.citation.endPage257pt_PT
oaire.citation.startPage225pt_PT
oaire.citation.titleAdvances in Experimental Medicine and Biologypt_PT
oaire.citation.volume(Advances in Experimental Medicine and Biology;1357)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRolo
person.familyNameSilva
person.familyNameLouro
person.givenNameDora
person.givenNameMaria João
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id7E16-CFCA-B797
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0003-4327-2279
person.identifier.orcid0000-0001-8821-0747
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
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