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Proteomics in the assessment of the therapeutic response of antineoplastic drugs: strategies and practical applications

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dc.contributor.authorTorres, Vukosava Milic
dc.contributor.authorPopovic, Lazar
dc.contributor.authorVaz, Fatima
dc.contributor.authorPenque, Deborah
dc.date.accessioned2016-10-06T12:31:48Z
dc.date.available2016-10-06T12:31:48Z
dc.date.issued2016
dc.description.abstractUncovering mechanisms of unknown pathological mechanisms and body response to applied medication are the drive forces toward personalized medicine. In this post-genomic era, all eyes are tuned to proteomic field, searching for the answers and explanations by investigating the final physiological functional units – proteins and their proteoforms. Development of cutting-edge mass spectrometric technologies and powerful bioinformatics tools, allowed life-science community mining of disease-specific proteins as biomarkers, which are often hidden by high complexity of the samples and/or small abundance. Nowadays, there are several proteomics-based approaches to study the proteome. This chapter focuses on gold standard proteomics strategies and related issues towards candidate biomarker discovery, which may have diagnostic/prognostic as well as mechanistic utility.pt_PT
dc.identifier.citationIn: Rueff J, Rodrigues AS (eds.). Cancer Drug Resistance: Overviews and Methods, Springer, 2016: 281-298pt_PT
dc.identifier.isbn978-1-4939-3347-1
dc.identifier.urihttp://hdl.handle.net/10400.18/4026
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationhttp://www.springer.com/gp/book/9781493933457
dc.subjectGenomica Funcionalpt_PT
dc.subjectMonitorização de Drogaspt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.subjectCancerpt_PT
dc.subjectChemotherapeutic Responsept_PT
dc.subjectDiscovery-based Proteomicspt_PT
dc.subjectProteomicspt_PT
dc.subjectTarget-proteomicspt_PT
dc.titleProteomics in the assessment of the therapeutic response of antineoplastic drugs: strategies and practical applicationspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage298pt_PT
oaire.citation.startPage281pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typebookPartpt_PT

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