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Advisor(s)
Abstract(s)
Uncovering mechanisms of unknown pathological mechanisms and body response to applied medication are the drive forces toward personalized medicine. In this post-genomic era, all eyes are tuned to proteomic field, searching for the answers and explanations by investigating the final physiological functional units – proteins and their proteoforms. Development of cutting-edge mass spectrometric technologies and powerful bioinformatics tools, allowed life-science community mining of disease-specific proteins as biomarkers, which are often hidden by high complexity of the samples and/or small abundance. Nowadays, there are several proteomics-based approaches to study the proteome. This chapter focuses on gold standard proteomics strategies and related issues towards candidate biomarker discovery, which may have diagnostic/prognostic as well as mechanistic utility.
Description
Keywords
Genomica Funcional Monitorização de Drogas Genómica Funcional e Estrutural Cancer Chemotherapeutic Response Discovery-based Proteomics Proteomics Target-proteomics
Pedagogical Context
Citation
In: Rueff J, Rodrigues AS (eds.). Cancer Drug Resistance: Overviews and Methods, Springer, 2016: 281-298