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Mixtures health effects: mycotoxins in food

2018-05-11Conference object Restricted access
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dc.contributor.authorPinhão, Mariana
dc.contributor.authorLoureiro, Susana
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorAlvito, Paula
dc.contributor.authorSilva, Maria João
dc.date.accessioned2019-02-25T13:53:33Z
dc.date.available2019-02-25T13:53:33Z
dc.date.issued2018-05-11
dc.description.abstractIn recent years, the risk assessment paradigm has shifted from the single-exposure and single-chemical adverse effect scenario to the one of multiple exposures and combined adverse effects. The present work describes the in vitro combined toxicity of mycotoxins at the renal level, as a case study. Mycotoxins are often present in food and feed, as secondary metabolites of contaminating fungi and human co-exposure mainly occurs though diet. Even though predictions about the toxic effects of mycotoxins mixtures can be based on their individual toxicities, experimental data is still limited to allow a reliable hazard assessment. This study aimed at characterizing the combined cytotoxic and genotoxic effects of ochratoxin A (OTA) and fumonisin B1 (FB1), in a kidney human cell line. The toxicity of several combinations of OTA and FB1 was compared with their individual toxicities (MTT assay) and interactions were ascertained using the reference models of concentration addition and independent action. A synergistic pattern for combinations of FB1 with the lower doses of OTA was detected, shifting to antagonism at higher dose levels, irrespectively of the reference model applied. Neither OTA nor FB1, individually or in combination, were genotoxic. In conclusion, this study revealed that, OTA and FB1 exert a synergistic toxic effect at the lowest dose levels, which are the most realistic ones in terms of human co-exposure. This finding emphasizes the relevance of assessing the combined toxicity of mycotoxins to allow the development of qualitative/semi-quantitative or probabilistic models for the hazard assessment of combined human exposure to these food contaminants.pt_PT
dc.description.sponsorshipThis research was supported by the FCT: MYCOMIX project (PTDC/DTP-FTO/0417/2012),, CESAM (UID/AMB/50017/2013 and ToxOmics (UID/BIM/00009/2013).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5938
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.subjectMixturespt_PT
dc.subjectMycotoxinspt_PT
dc.subjectToxicitypt_PT
dc.subjectFood Safetypt_PT
dc.subjectOchratoxin Apt_PT
dc.subjectFumonisin B1pt_PT
dc.subjectCombined Effectpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectSegurança Alimentar
dc.titleMixtures health effects: mycotoxins in foodpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title1st Workshop on Human Biomonitoring in Portugal "Bridging Chemical Exposure to Human Health", INSA, 11 May 2018pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameLouro
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
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