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The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population

2017-08-15Journal article Restricted access
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dc.contributor.authorBettencourt, Andreia
dc.contributor.authorBoleixa, Daniela
dc.contributor.authorGuimarães, Ana Luísa
dc.contributor.authorLeal, Bárbara
dc.contributor.authorCarvalho, Cláudia
dc.contributor.authorBrás, Sandra
dc.contributor.authorSamões, Raquel
dc.contributor.authorSantos, Ernestina
dc.contributor.authorCosta, Paulo Pinho
dc.contributor.authorSilva, Berta
dc.contributor.authorda Silva, Ana Martins
dc.date.accessioned2018-03-22T19:55:39Z
dc.date.available2018-03-22T19:55:39Z
dc.date.issued2017-08-15
dc.description.abstractThe cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. The purpose of this study was to evaluate the influence of FokI VDR polymorphism in MS development and progression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Neuroimmunol. 2017 Aug 15;309:34-37. doi: 10.1016/j.jneuroim.2017.05.005. Epub 2017 May 11.pt_PT
dc.identifier.doi10.1016/j.jneuroim.2017.05.005pt_PT
dc.identifier.issn0165-5728
dc.identifier.urihttp://hdl.handle.net/10400.18/5467
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/International Society for Neuroimmunologypt_PT
dc.relation.publisherversionhttp://www.jni-journal.com/article/S0165-5728(17)30069-3/fulltextpt_PT
dc.subjectAdultpt_PT
dc.subjectDeoxyribonucleases, Type II Site-Specificpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMultiple Sclerosispt_PT
dc.subjectPolymorphism, Single Nucleotidept_PT
dc.subjectPortugalpt_PT
dc.subjectReceptors, Calcitriolpt_PT
dc.subjectYoung Adultpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleThe vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage37pt_PT
oaire.citation.startPage34pt_PT
oaire.citation.titleJournal of Neuroimmunologypt_PT
oaire.citation.volume309pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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