The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population

The cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. The purpose of this study was to evaluate the influence of FokI VDR polymorphism in MS development and progression.

Palavras-chave

Adult Deoxyribonucleases, Type II Site-Specific Female Humans Male Multiple Sclerosis Polymorphism, Single Nucleotide Portugal Receptors, Calcitriol Young Adult Doenças Genéticas

URI

http://hdl.handle.net/10400.18/5467

Citação

J Neuroimmunol. 2017 Aug 15;309:34-37. doi: 10.1016/j.jneuroim.2017.05.005. Epub 2017 May 11.

Editora

Elsevier/International Society for Neuroimmunology

DOI

10.1016/j.jneuroim.2017.05.005

Coleções

DGH - Artigos em revistas internacionais

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