Loading...
Publication
sdLDL como potencial biomarcador no diagnóstico e prevenção de doença cardiovascular em diabéticos
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 647.5 KB | Adobe PDF |
Advisor(s)
Abstract(s)
As doenças cardiovasculares (DCV) são a principal causa de morbilidade
e mortalidade a nível mundial. De entre os fatores de risco conhecidos
para as DCV, destacam-se a dislipidemia, a hipertensão, a diabetes
e o excesso de peso/obesidade. As lipoproteínas de baixa densidade
(LDL) constituem um dos marcadores bioquímicos recomendados para
diagnosticar as DCV. No entanto, as lipoproteínas mais pequenas e mais
densas - small dense LDL (sdLDL) - parecem ter um efeito mais aterogénico,
refletindo-se num risco acrescido de DCV. O doseamento de sdLDL
tem demonstrado em diferentes estudos um aumento da sua concentração
em indivíduos com Diabetes Mellitus do tipo 2. Este estudo pretende
investigar esta associação na população portuguesa, tendo por base
uma população do estudo e_COR. Foram determinados alguns parâmetros
bioquímicos no sangue e reunidos dados clínicos através de questionários.
As análises estatísticas foram realizadas através do programa
IMB SPSS Statistics 22. Os resultados deste estudo evidenciaram que
os indivíduos diabéticos apresentam níveis de sdLDL superiores aos não
diabéticos, registando-se uma forte associação entre o rácio sdLDL/LDL
e a diabetes. A determinação deste rácio pode vir assim a ser considerada
como um potencial biomarcador para diagnóstico de DCV em diabéticos,
embora sejam necessários mais estudos epidemiológicos para uma
conclusão mais definitiva.
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. Among the known risk factors for CVD we highlight dyslipidemia, hypertension, diabetes and overweight. The Low-density lipoproteins (LDL) are one of the recommended biochemical markers to diagnose CVD. However, the small dense lipoproteins (sdLDL) appears to have a more atherogenic effect, reflecting increased risk of CVD. Quantification of sdLDL have demonstrated in different studies an increase of its concentration in individuals with Type 2 Diabetes Mellitus. In the present study, we propose to investigate this association in the Portuguese population, using the e_COR sample. The biochemical parameters were determined in the blood and clinical data was collected through questionnaires. Statistical analyzes were performed using the IMB SPSS 22 Statistics program. Results showed that diabetic subjets have higher levels of sdLDL than non-diabetics, with a strong association between the sdLDL/LDL ratio and diabetes. Determination of this ratio may thus be considered as a potential biomarker for diagnosis of CVD in diabetics, although more epidemiological studies are needed for a more definitive conclusion.
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. Among the known risk factors for CVD we highlight dyslipidemia, hypertension, diabetes and overweight. The Low-density lipoproteins (LDL) are one of the recommended biochemical markers to diagnose CVD. However, the small dense lipoproteins (sdLDL) appears to have a more atherogenic effect, reflecting increased risk of CVD. Quantification of sdLDL have demonstrated in different studies an increase of its concentration in individuals with Type 2 Diabetes Mellitus. In the present study, we propose to investigate this association in the Portuguese population, using the e_COR sample. The biochemical parameters were determined in the blood and clinical data was collected through questionnaires. Statistical analyzes were performed using the IMB SPSS 22 Statistics program. Results showed that diabetic subjets have higher levels of sdLDL than non-diabetics, with a strong association between the sdLDL/LDL ratio and diabetes. Determination of this ratio may thus be considered as a potential biomarker for diagnosis of CVD in diabetics, although more epidemiological studies are needed for a more definitive conclusion.
Description
Keywords
Diabetes Doença Cardiovascular Biomarcadores sdLDL Diagnóstico de Doença Prevenção de Doença Acidente Vascular Cerebral Doença Arterial Coronária Doenças Cardio e Cérebro-vasculares
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2017 janeiro-abril;6(18):28-31
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP