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Effect of cytochalasin-B on TIO2 nanoparticles uptake by different cell lines

2018-11Conference object Restricted access
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dc.contributor.authorBrandão, Fátima
dc.contributor.authorCosta, Carla
dc.contributor.authorFraga, Sónia
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorLaffon, Blanca
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2019-03-06T17:54:01Z
dc.date.available2019-03-06T17:54:01Z
dc.date.issued2018-11
dc.description.abstractThe in vitro cytokinesis-block micronucleus cytome assay (CBMN) is widely used for genotoxicity evaluation of nanomaterials (NMs). However, cytochalasin-B (Cyt-B) used in this test may affect the uptake of NMs due to possible interference with endocytosis. Thus, the aim of this study was to investigate the influence of Cyt-B on the uptake of TiO2 nanoparticles (TiO2 NPs) by four different human cell lines: lung cells (A549), glial cells (A172), neurons (SH-SY5Y), and liver cells (HepG2).pt_PT
dc.description.sponsorshipThis work was supported by Xunta de Galicia (reference ED431B 2016/013). F. Brandão is supported by the grant SFRH/BD/101060/2014, funded by FCT (subsidized by national fund of MCTES) and V. Valdiglesias by a Xunta de Galicia postdoctoral fellowship (reference ED481B 2016/190-0).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6089
dc.language.isoengpt_PT
dc.subjectCytochalasin-Bpt_PT
dc.subjectCytokinesis-block Micronucleus Cytome Assaypt_PT
dc.subjectNanoparticlespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleEffect of cytochalasin-B on TIO2 nanoparticles uptake by different cell linespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceGrenoble, France​pt_PT
oaire.citation.title6th International Conference nanoSAFE 2018, 5- 9 November 2018pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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