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High-Dose Quadrivalent vs Standard Dose Influenza Vaccine Effectiveness using EHR in Portugal

2025-09-26Documento de conferência Acesso aberto
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datacite.subject.fosCiências Naturais::Matemáticas
datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorBrito, André
dc.contributor.authorSoares, Patrícia
dc.contributor.authorGómez, Verónica
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorLeite, Andreia
dc.contributor.authorMachado, Ausenda
dc.date.accessioned2026-03-09T16:29:23Z
dc.date.available2026-03-09T16:29:23Z
dc.date.issued2025-09-26
dc.description.abstractThis study presents an updated protocol to assess the effectiveness of the high-dose quadrivalent influenza vaccine (HD-QIV) in preventing hospitalisation due to influenza-like illness among older adults in Portugal. Using routinely collected electronic health records, we will conduct a retrospective cohort study covering the 2022/23 to 2025/26 influenza seasons, including residents of long-term care facilities and community-dwelling individuals eligible for HD or standard-dose vaccination. Vaccine exposure will be defined 14 days post-administration, and outcomes will include first hospitalisation related to influenza or associated complications. Relative and absolute vaccine effectiveness will be estimated using Cox proportional hazards models. Key challenges include potential misclassification of residence and outcomes, uneven vaccine rollout, and small sample sizes in some groups; we will address these through sensitivity analyses, spatio-temporal assessments, and propensity-score matching where appropriate. The study will provide timely evidence on HD-QIV performance in real-world conditions, supporting national vaccination strategies for high-risk populations. This was a presentation made at the annual VEBIS Consortium LOT 4.eng
dc.identifier.urihttp://hdl.handle.net/10400.18/11264
dc.language.isoeng
dc.peerreviewedn/a
dc.relationVEBIS-ECDC-Lot 4
dc.rights.uriN/A
dc.subjectHigh-Dose Vaccination
dc.subjectLTCF Residents
dc.subjectVaccine Effectiveness
dc.subjectEstados de Saúde e de Doença
dc.subjectInfecções Respiratórias
dc.titleHigh-Dose Quadrivalent vs Standard Dose Influenza Vaccine Effectiveness using EHR in Portugaleng
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferenceDate2025-09-26
oaire.citation.conferencePlaceBruxelas, Bélgica
oaire.citation.titleVEBIS EHR Annual Meeting 2025, 26 september 2025
oaire.versionhttp://purl.org/coar/version/c_fa2ee174bc00049f

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