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- Iron metabolism genes shape the course of liver fibrosis in chronic hepatitis C: from disease progression to reversal after direct-acting antivirals treatmentPublication . Ferreira, Joana; Bicho, Manuel; Faustino, Paula; Serejo, FátimaChronic hepatitis C (CHC) is linked to iron overload, which significantly correlates with liver fibrosis. This study aimed to assess whether genetic polymorphisms related to iron metabolism are associated with fibrosis severity, predict improvement in fibrosis after HCV clearance with direct-acting antivirals (DAAs) and influence iron-related metabolic markers before treatment. A total of 329 CHC patients were included, 134 of whom received DAAs therapy. Liver fibrosis was assessed using transient elastography (FibroScan), and biochemical parameters were measured using standard methods. Eighteen genetic polymorphisms within five iron metabolism-related genes were analyzed using PCR-RFLP, endpoint genotyping, or next-generation sequencing (NGS). Before DAA treatment, patients with severe f ibrosis showed higher levels of serum iron (Fe), total iron-binding capacity (TIBC), and ferritin (Ft). SLC40A1 rs1439816_GG was associated with an increased risk of severe fibrosis. compared with GC or CC genotypes. SLC40A1 rs11568351_GC genotype was linked to a higher likelihood of remaining cirrhotic after HCV clearance. Elevated iron parameters were observed in carriers HFE C282Y_CY, TF IVS 11 G>A, and BMP2 570 A>T. Overall, polymorphisms in iron metabolism genes may influence both the severity of liver fibrosis prior to treatment, its regression after DAA therapy and the regulation of iron metabolism in CHC patients.
- X_Actividade Dinâmica para a Noite Europeia dos Investigadores 2025Publication . Brito, André; Saraiva, Ana LeonorDashboard interactivo desenhando especificamente para apresentar o trabalho do DEP na Noite Europeia dos Investigadores em 2025 em Lisboa. Inclui duas actividades, uma que apresenta de forma dinâmica como é feita a modelação matemática de dinâmicas de doença com modelos compartimentais com exemplos e histórias ilustrativas e uma outra atividade que apresenta como são estimados o risco de morte em caso de exposição a temperaturas altas.
- High-Dose Quadrivalent vs Standard Dose Influenza Vaccine Effectiveness using EHR in PortugalPublication . Brito, André; Soares, Patrícia; Gómez, Verónica; Rodrigues, Ana Paula; Leite, Andreia; Machado, AusendaThis study presents an updated protocol to assess the effectiveness of the high-dose quadrivalent influenza vaccine (HD-QIV) in preventing hospitalisation due to influenza-like illness among older adults in Portugal. Using routinely collected electronic health records, we will conduct a retrospective cohort study covering the 2022/23 to 2025/26 influenza seasons, including residents of long-term care facilities and community-dwelling individuals eligible for HD or standard-dose vaccination. Vaccine exposure will be defined 14 days post-administration, and outcomes will include first hospitalisation related to influenza or associated complications. Relative and absolute vaccine effectiveness will be estimated using Cox proportional hazards models. Key challenges include potential misclassification of residence and outcomes, uneven vaccine rollout, and small sample sizes in some groups; we will address these through sensitivity analyses, spatio-temporal assessments, and propensity-score matching where appropriate. The study will provide timely evidence on HD-QIV performance in real-world conditions, supporting national vaccination strategies for high-risk populations. This was a presentation made at the annual VEBIS Consortium LOT 4.