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Moderate influenza vaccine effectiveness in a B mismatch season: preliminary results from the 2017/2018 season in Portugal

2018-07-11Journal article Open access
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dc.contributor.authorMachado, Ausenda
dc.contributor.authorKislaya, Irina
dc.contributor.authorNunes, Baltazar
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorEuroEVA project
dc.date.accessioned2019-02-13T11:09:12Z
dc.date.available2019-02-13T11:09:12Z
dc.date.issued2018-07-11
dc.descriptionLetters to editorpt_PT
dc.description.abstractThis study aimed to provide early 2017/2018 seasonal IVE using data from the Portuguese influenza surveillance system. This analysis included patients with influenza-like illness (ILI) from primary care and emergency departments swabbed for the detection of influenza using RT-PCR between weeks 38/2017 to 5/2018. We used the test-negative case–control study design, where influenza laboratory confirmed incident ILI patients (Cases) were compared to laboratory influenza negative ILI patients (Controls). IVE analysis was restricted to ILI patients with symptoms compatible with the European Union ILI definition, i.e., with sudden onset of at least one systemic and one respiratory symptom. Chi-square test was used to compare baseline characteristics between Cases and Controls. Crude IVE, design adjusted for calendar time, was estimated using 1-odds ratio (OR) of being vaccinated in Cases vs. Controls and was further adjusted for confounding by age group and presence of chronic condition.A total of 732 ILI patients were reported to the NISS and approximately 74% adhered to the ILI definition. In a season with B/Yamagata dominance and with vaccine lineage mismatch, the 2017/2018 trivalent seasonal influenza vaccine conferred moderate protection against medically attended influenza. The use of surveillance data constituted a useful tool to have early in the season IVE estimates. These results assist modifications to health interventions, such as using antiviral treatment in high-risk patients, reinforcement of social eviction and individual hygiene measures to reduce risk of influenza transmission, regardless of the vaccination status.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPulmonology. 2018 Jul-Aug;24(4):260-262. doi: 10.1016/j.pulmoe.2018.05.004. Epub 2018 Jun 11.pt_PT
dc.identifier.doi10.1016/j.pulmoe.2018.05.004pt_PT
dc.identifier.issn2531-0437
dc.identifier.urihttp://hdl.handle.net/10400.18/5777
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/Portuguese Society of Pulmonologypt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2531043718300801?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInfluenzapt_PT
dc.subjectVaccine Effectivenesspt_PT
dc.subjectPortuguese Influenza Surveillance Systempt_PT
dc.subjectPortuguese Populationpt_PT
dc.subjectEuroEVApt_PT
dc.subjectGripept_PT
dc.subjectVacina Antigripalpt_PT
dc.subjectÉpoca 2017/2018pt_PT
dc.subjectEfetividade da vacinapt_PT
dc.subjectCuidados de Saúdept_PT
dc.subjectInfecções Respiratórias
dc.titleModerate influenza vaccine effectiveness in a B mismatch season: preliminary results from the 2017/2018 season in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage262pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage260pt_PT
oaire.citation.titlePulmonologypt_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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