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Functional effects of differentially expressed microRNAs in alveolar epithelial cells exposed to MWCNT-7 or crocidolite

2019-03-21Conference object Restricted access
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dc.contributor.authorVentura, Célia
dc.contributor.authorVieira, Luís
dc.contributor.authorSilva, Catarina
dc.contributor.authorSousa-Uva, Antonio
dc.contributor.authorSilva, Maria João
dc.date.accessioned2020-07-15T15:47:51Z
dc.date.available2020-07-15T15:47:51Z
dc.date.issued2019-03-21
dc.description.abstractBackground and Aims Multi-walled carbon nanotubes (MWCNT) are widely used engineered nanomaterials in industrial and biomedical applications, but their inhalation may induce pulmonary adverse effects. Moreover, the MWCNT-7 (Mitsui-7) has been classified as possibly carcinogenic to humans. Nevertheless, MWCNT-7 molecular modes of action are poorly understood and there are no biomarkers of exposure or effect for occupational monitoring. Recently, several pulmonary diseases, including lung cancer, have been associated with alterations in microRNA expression. These changes are potentially useful to detect or evaluate disease progression and to understand the molecular effects induced by the disease or toxicant. In this study, we describe a set of differentially expressed microRNAs (DE miRNAs) in A549 epithelial alveolar cells, following exposure to an occupationally relevant dose of MWCNT-7 or crocidolite. The functional pathways and ontology terms enriched with genes targeted by DE miRNAs were identified. Moreover, an interaction network of DE miRNAs-target cancer genes was constructed.pt_PT
dc.description.sponsorshipFoundation for Science and Technology, Centre for Toxicogenomics and Human Health ToxOmics under grant UID/BIM/00009 2013 and by ToxApp 4 NanoCELFI (PTDC/SAU PUB/ 32587 2017), GenomePT project (POCI 01 0145 FEDER 022184 supported by COMPETE 2020 Operational Programme for Competitiveness and Internationalisation ( Lisboa Portugal Regional Operational Programme (Lisboa 2020 Algarve Portugal Regional Operational Programme (CRESC Algarve 2020 under the PORTUGAL 2020 Partnership Agreement)pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7054
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.subjectmicroRNAspt_PT
dc.subjectMultiwalled Carbon Nanotubespt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleFunctional effects of differentially expressed microRNAs in alveolar epithelial cells exposed to MWCNT-7 or crocidolitept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleIV NOVAhealth Genetics Workshop, Universidade NOVA de Lisboa, 21 março 2019pt_PT
oaire.fundingStream5876
person.familyNameVentura
person.familyNameVieira
person.familyNameSousa-Uva
person.familyNameSilva
person.givenNameCélia
person.givenNameLuís
person.givenNameAntonio
person.givenNameMaria Joao
person.identifier2056460
person.identifierR-000-KJ8
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-idA412-ADF0-EAC5
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0002-7703-1409
person.identifier.orcid0000-0001-7751-5430
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id55781566100
person.identifier.scopus-author-id36857967200
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublicationed1872ad-c157-4863-9cb7-2dc8b93d6cce
relation.isAuthorOfPublication5df7c68f-af20-4ca0-937c-e213553753b5
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