A carregar...
Publicação
Functional effects of differentially expressed microRNAs in alveolar epithelial cells exposed to MWCNT-7 or crocidolite
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.07 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Background and Aims
Multi-walled carbon nanotubes (MWCNT) are widely used engineered nanomaterials in industrial and biomedical
applications, but their inhalation may induce pulmonary adverse effects. Moreover, the MWCNT-7 (Mitsui-7) has been
classified as possibly carcinogenic to humans. Nevertheless, MWCNT-7 molecular modes of action are poorly understood
and there are no biomarkers of exposure or effect for occupational monitoring. Recently, several pulmonary diseases,
including lung cancer, have been associated with alterations in microRNA expression. These changes are potentially
useful to detect or evaluate disease progression and to understand the molecular effects induced by the disease or
toxicant. In this study, we describe a set of differentially expressed microRNAs (DE miRNAs) in A549 epithelial alveolar
cells, following exposure to an occupationally relevant dose of MWCNT-7 or crocidolite. The functional pathways and
ontology terms enriched with genes targeted by DE miRNAs were identified. Moreover, an interaction network of DE
miRNAs-target cancer genes was constructed.
Descrição
Palavras-chave
microRNAs Multiwalled Carbon Nanotubes Environmental Genotoxicity Genotoxicidade Ambiental