Pharmacogenomics of dyslipidaemia drugs in Portugal

Chora, J.R.; Bourbon, M.

http://hdl.handle.net/10400.18/7718

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Pharmacogenomics of dyslipidaemia drugs in Portugal.pdf		355.86 KB	Adobe PDF	Download

Send Feedback

Authors

Chora, J.R.

Bourbon, M.

Abstract(s)

Background/Aim: Statins are the standard treatment for dyslipidaemia disorders, but there is a wide (10-70%) variation in patient response to statin treatment and several documented serious adverse effects. Studies of variants in genes regulating drug absorption, metabolism, pharmacodynamics and excretion mechanisms, have been implicated as reasons for this variability. The aim of this study is to determine the prevalence of pharmacogenetic relevant genotypes in the Portuguese population and in a sample of high cardiovascular risk patients: familial hypercholesterolemia subjects.