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Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci

2018-09Conference object Restricted access
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dc.contributor.authorBarros, Patricia
dc.contributor.authorAmaral, Andreia
dc.contributor.authorAbrantes, Leonor
dc.contributor.authorOliveira, Tiago
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria joão
dc.contributor.authorJordan, Peter
dc.contributor.authorGama-Carvalho, Margarida
dc.contributor.authorMatos, Paulo
dc.date.accessioned2019-02-13T16:15:12Z
dc.date.available2020-06-01T00:30:16Z
dc.date.issued2018-09
dc.description.abstractColorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.pt_PT
dc.description.sponsorshipFunding support by FCT (IF2012 and PTDC/SAU/GMG/119586/2010 to PM; SFRH/BPD/94322/2013 to PB; SFRH/BPD/65976/2009 and EMBO long-term fellowship ALT-33-2010 to AJA; centre grant UID/MULTI/04046/2013 to BioISI).pt_PT
dc.description.versioninfo:eu-repo/semantics/draftpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5797
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectColorectal Cancerpt_PT
dc.subjectBCL6pt_PT
dc.subjectRAC1pt_PT
dc.subjectDNA Damagept_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.titleStimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed locipt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-GMG%2F119586%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F94322%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F65976%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleSINAL 2018- 9th international meeting on signal transduction, 21-22 September 2018pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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