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Publication
Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci
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Advisor(s)
Abstract(s)
Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.
Description
Keywords
Colorectal Cancer BCL6 RAC1 DNA Damage Vias de Transdução de Sinal e Patologias Associadas