Untitled

Funder

Organizational Unit

Publications

Pairwise toxicity evaluation of ceramic nanoparticles in submerged and air-liquid interface cultures of human alveolar epithelial A549 cells

Publication . Bessa, Maria João; Fraga, Sónia; Brandão, Fátima; Fokkens, Paul; Boere, J.; Leseman, D.; Salmatonidis, A.; Viana, Mar; Cassee, Flemming; Teixiera, João Paulo

Objectives: To investigate the in vitro toxicity of ceramic NPs (CeO2, ZrO2 and Sb2O3•SnO2 NPs) in human alveolar epithelial cells, a primary target during inhalation exposure, in both submerged and air-liquid cell cultures

2018-10Conference object

Restricted access

Toxicity of ceramic nanoparticles in human alveolar epithelial A549 cells at air-liquid interface

Publication . Fraga, Sónia; Bessa, Maria João; Brandão, Fátima; Fokkens, Paul; Salmatonidis, A.; Viana, Mar; Cassee, Flemming; Teixeira, João Paulo

Several ceramic industries have already incorporated within their production processes the manufacture of different types of ceramic nanoparticles (NPs), as well as the application of those nanomaterials on conventional products, which increases the risk of human exposure to these nanoparticles, particularly in occupational settings. The aim of this study was to investigate the in vitro toxicity of ceramic NPs (ZrO2, CeO2 and Sb2O3•SnO2 NPs) in human alveolar epithelial cells, a primary target following inhalation exposure.

2018-11Conference object

Restricted access

Toxicity assessment of engineered and airborne process-generated nanoparticles in human alveolar epithelial A549 cells

Publication . Bessa, Maria João; Fraga, Sónia; Brandão, Fátima; Salmatonidis, A.; Viana, Mar; Cassee, Flemming; Teixeira, João Paulo

Nanotechnology offers many possibilities in the ceramic sector by providing innovation of the industrial processes and products. However, nanoparticles (NPs) used in the manufacture of ceramic goods or released to the workplace air during production may pose a serious hazard for human health. This study aimed to investigate in vitro toxicity of both engineered (ENPs) (ZrO2, CeO2, SnO2 and Sb2O3•SnO2) and process-generated nanoparticles (PGNPs) [released during High Velocity Oxy-Fuel (HVOF) spraying] in human alveolar epithelial cells, a primary target following inhalation exposure.

2018-11Conference object

Restricted access

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

Publication . Bessa, Maria João; Brandão, Fátima; Viana, Mar; Gomes, João F.; Monfort, Eliseo; Cassee, Flemming R.; Fraga, Sónia; Teixeira, João Paulo

The ceramic industry is an industrial sector of great impact in the global economy that has been benefiting from advances in materials and processing technologies. Ceramic manufacturing has a strong potential for airborne particle formation and emission, namely of ultrafine particles (UFP) and nanoparticles (NP), meaning that workers of those industries are at risk of potential exposure to these particles. At present, little is known on the impact of engineered nanoparticles (ENP) on the environment and human health and no established Occupational Exposure Limits (OEL) or specific regulations to airborne nanoparticles (ANP) exposure exist raising concerns about the possible consequences of such exposure. In this paper, we provide an overview of the current knowledge on occupational exposure to NP in the ceramic industry and their impact on human health. Possible sources and exposure scenarios, a summary of the existing methods for evaluation and monitoring of ANP in the workplace environment and proposed Nano Reference Values (NRV) for different classes of NP are presented. Case studies on occupational exposure to ANP generated at different stages of the ceramic manufacturing process are described. Finally, the toxicological potential of intentional and unintentional ANP that have been identified in the ceramic industry workplace environment is discussed based on the existing evidence from in vitro and in vivo inhalation toxicity studies.

2020-05Journal article

Restricted access