DEP - Apresentações orais em encontros internacionais
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- Congenital Anomalies and Cerebral Palsy: Data from the Portuguese Cerebral Palsy Surveillance ProgramPublication . Cadete, Ana; Folha, Teresa; Braz, Paula; Calado, Eulália; Alvarelhão, Joaquim; Virella, DanielBackground and Objectives: Attention was recently drawn to the association of congenital anomalies (CA) with severity and complexity of cerebral palsy (CP). Evidence of this association is presented. Participants-Methods: The Portuguese National Surveillance of Cerebral Palsy (PNSCP) registers data of 5-to-8-year-old children with CP, born since 2001. The PNSCP follows the Surveillance of Cerebral Palsy in Europe (SCPE) common database protocol. Data were cross-referenced with the Portuguese National Registry of Congenital Anomalies. Children born between 2001-2015, notified until September 2024, were analyzed. CA were characterized according to ICD-10, following the EUROCAT criteria. Associations between the clinical forms of CP, complexity indicators and the presence of CA were explored. Results: Of 2251 registered children, 603 (27%; 95%CI 24.9-28.6) had at least one CA recorded; 228 children had multiple CA (10%; 95%CI 8.9-11.4). CA of the nervous system Q00-Q07 (CANS) are the most frequent (16%; 95%CI 14.9-18.0), followed by CA of the circulatory system Q20-Q28 (CACS) (4.9%; 95%CI 4.1-59). The odds of having at least one indicator of CP complexity increases by 2.6 times when having a CA (OR 2.6; 95%CI 2.01-3.48); slightly higher if a CANS exists (2.9; 95%CI 2.06-4,21), and slightly lower if a CACS exists (1.6; 95%CI 0.98-2.83). Conclusion: The prevalence of CA in children with CP is much higher than in the general population and increases the odds for greater severity and/or complexity of CP. The odds seems to be higher in the presence of CANS. This should be considered when assessing the prognosis and planning intervention.
- Tracking Mycotoxin Exposure in Portugal: New Insights and Key DeterminantsPublication . Namorado, Sónia; Maris, Elias; Chen, A.; Pero-Gascon, Roger; de Boevre, Marthe; De Saeger, Sarah; Silva, Maria João; Alvito, Paula; .Human biomonitoring (HBM) is a vital tool for assessing exposure to environmental chemicals. Mycotoxins have been associated with various adverse health effects, including estrogenic, immunotoxic, nephrotoxic, and teratogenic outcomes. In this presentation an overview of two recent HBM studies on multiple mycotoxins exposure biomarkers conducted in Portugal will be given. The first study analyzed 37 mycotoxin biomarkers in urine samples from 94 adult participants (48.4 ± 15.2 years), as part of the National Food, Nutrition, and Physical Activity Survey (2015–2016). Six different mycotoxins -DON, ZEN, AOH, OTA, FB1, and CIT- was confirmed through the quantification of 12 urinary biomarkers in paired 24 h and first-morning urine samples. DON and its metabolites were among the most frequently detected biomarkers and AOH was identified for the first time in urine samples from a European population. Associations between urinary mycotoxin biomarkers and consumption of specific food items were also observed. More recently, a subset of 295 first-morning urine samples from adults (28–39 years) was collected between 2019-2020, as part of a cross-sectional study embedded within the Portuguese National Health Examination Survey (INSEF). These samples were analyzed using a newly optimized and validated LC-MS/MS method capable of detecting 40 mycotoxins and/or their metabolites in urine. DON and tenuazonic acid were the most frequently detected, with detection rates of 85% and 96%, respectively. Further investigations into key exposure determinants—including dietary habits, demographic factors, and geographical variations—are ongoing and will be presented. Altogether, these findings highlight the importance of continued surveillance and the integration of HBM into national food safety and public health strategies.