Browsing by Issue Date, starting with "2021-04-30"
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- Cardiovascular risk and pharmacogenetics of statins in Familial HypercholesterolaemiaPublication . Chora, JoanaFamilial hypercholesterolemia is a cardiovascular disease risk condition since its characterized by elevated lipid values since childhood. In this work we stratified CVD risk in a sample of FH patients and the general population and analysed both cohorts in terms of lipid lowering therapy used and attainment of lipid therapeutic target levels. We saw that while the general population has moderate to high CVD risk, FH patients have high to very high CVD risk. Lipid target levels are not being met and the higher risk groups are the worst controlled. Additionally we studied the association between the genotype of specific statin pharmacogenetic relevant SNPs and lipid values after statin treatment and found that APOE rs7412 is associated with higher LDL values after statin treatment and failure to achieve target lipid levels. Predicting the effect of lipid lowering drugs based on the individual’s genetic background allows for appropriate therapeutic strategies, optimizing therapeutic benefits and minimizing toxicity risk in the individual patient.
- Relatório REVIVE 2020 - Culicídeos e Ixodídeos: Rede de Vigilância de VetoresPublication . Centro de Estudos de Vetores e Doenças Infeciosas Doutor Francisco CambournacRelatório Culicídeos e Ixodídeos relativo a 2020, desenvolvido no âmbito das atividades da Rede de Vigilância de Vetores (REVIVE). O programa REVIVE resulta da colaboração entre instituições do Ministério da Saúde (Direção-Geral da Saúde, Administrações Regionais de Saúde, Instituto dos Assuntos Sociais e da Saúde da Madeira, Direção Regional de Saúde dos Açores e INSA), tendo como objetivos i) monitorizar a atividade de artrópodes hematófagos; ii) caraterizar as espécies e sua ocorrência sazonal; iii) identificar agentes patogénicos importantes em saúde pública, dependendo da densidade dos vetores, o nível de infeção ou a introdução de espécies exóticas para alertar para as medidas de controlo. O REVIVE tem contribuído para um conhecimento sistemático da fauna de culicídeos e de ixodídeos de Portugal, e do seu potencial papel de vetor, constituindo uma componente dos programas de vigilância epidemiológica indispensável à avaliação do risco de transmissão de doenças potencialmente graves.
- Prevalence of COVID-19 in health professionals and occupational psychosocial risksPublication . Sousa-Uva, Mafalda; Sousa-Uva, António; Serranheira, FlorentinoIntroduction: Health professionals who provide clinical care are exposed to patients potentially infected by the severe acute respiratory syndrome coronavirus 2 SARS-CoV-2), namely physicians and nurses; consequently, these professionals face higher risks of infection. Objectives: This study aimed to describe the prevalence of coronavirus disease 19 (COVID-19) cases among health professionals and the frequencies of risk factors and psychosocial risk. Methods: This is a cross-sectional study targeted at health professionals working in Portugal during the current COVID-19 pandemic. Data were obtained through a self-administered questionnaire available online at the websites of medical and nursing boards, among other sources. We performed a univariate analysis, calculating absolute and relative frequencies, and a bivariate analysis with a Pearson's chi-squared test. Results: We studied 4,212 health professionals, of which 36.7% (n = 1,514) worked in areas dedicated to the treatment of sick or suspected COVID-19 patients. Of these, 2.11% tested positive for SARS-CoV-2. Among all participants, 76.7% and 79.1% presented moderate to severe levels of fatigue and anxiety, respectively. Fatigue levels were significantly higher in professionals working in areas dedicated to the treatment of patients with COVID-19 (80.5% p = 0.01), but this difference was not observed regarding anxiety (79.5% p = 0.681). Conclusions: The percentage of health professionals who tested positive for SARS-CoV-2 was 2.11%. The reported high levels of fatigue and anxiety should determine a better protection of the health and safety of those who provide health care in the current pandemic.