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- Obstructive Sleep Apnea: New insights into antioxidant activity and cellular response to stressPublication . Vaz, Fátima; Feliciano, Amélia; Silva, Ana Rita; Coelho, Cristina; Torres, Vukosava Millic; Bozanic, Vesna; Malhotra, Atul; Pinto, Paula; Bárbara, Cristina; Penque, DeborahObstructive sleep apnea (OSA) is a sleep¬related breathing disorder characterized by recurrent episodes of apnea/and hypopnea during sleep with resultant intermittent hypoxia and sleep fragmentation, leading to cardiometabolic diseases. OSA affects 3.7% to 26% of adult population, but frequently is underdiagnosed. By 2DIGE-proteomics approach, we have investigated red blood cells (RBC) in OSA to uncover new insights into putative chronic stress-induced RBC dysfunction that lead to inflammation and metabolic syndrome associated with OSA. A number of proteins as potential candidate biomarkers for OSA, such as the cytosolic antioxidant regulators, catalase (CAT) and peroxiredoxin2 (PRX2) was identified, needing additional biochemical research validation.
- Second-hand tobacco smoke effects evaluated by proteomicsPublication . Pacheco, Solange; Vaz, Fatima; penque, deborah; Neves, Sofia; Torres, VukosavaSecond-hand smoke (SHS) is responsible for more then 600000 premature year deaths. In the European Union, 14% of Non-Smokers (NS) are exposed to other individuals’ tobacco smoke at home and 30% are exposed at the workplace. Towards their protection several European countries, except Portugal, move to a total tobacco ban in indoor public places. In 2008, a project aiming to analyze the impact of partial smoking ban in Portuguese public venues started. After our previously evidence of both SHS air contamination in non-smoking areas and inhalation of tobacco smoke by the venues workers, we aimed to study resultant biochemical and molecular changes at both systemic and respiratory level.
- Proteomics of Red Blood Cells from Patients with Obstructive Sleep ApneaPublication . Feliciano, Amelia; Bozanic, Vesna; Torres, Vukosava Milic; Matthiesen, Rune; Carvalho, Ana S.; Almeida, Andreia; Alexandre, Bruno; Vaz, Fátima; Malhotra, Atul; Pinto, Paula; Bárbara, Cristina; Penque, DeborahObstructive sleep apnea (OSA) is a common public health concern causing metabolic and cardiovascular consequences. Although OSA is a systemic disease, the molecular mechanisms and specific genes/proteins associated with such processes remain poorly defined.To identify dysregulated proteins that could be useful as candidate biomarkers of diagnosis/prognosis of OSA., is the aim of this study
- Antioxidant properties of coriander essential oil and linalool and their potential to control Campylobacter spp.Publication . Duarte, A.; Luís, A.; Oleastro, Mónica; Domingues, F.C.Foodborne diseases remain common around the world with Campylobacteriosis being the most commonly reported zoonosis in the European Union in 2013. Campylobacter jejuni and Campylobacter coli are the main species associated with human illness. Furthermore, Campylobacter can develop biofilms which is becoming a major problem within the food industry. In addition to foodborne pathogens, oxidation is a non-microbial cause of deterioration of food causing loss of quality and safety. Thus, there is an urgent need in the food industry for new and effective strategies that can help prevent food contamination, spoilage and consequently, foodborne illnesses. Essential oils are known for their antimicrobial and antioxidant properties and are already widely used in the food industry. So, the aim of this work was to study the antimicrobial and anti-biofilm activity of coriander essential oil and its major compound linalool against C. jejuni and C. coli strains, as well as their effect in the quorum sensing (QS) system and their potential as antioxidants. Our results, demonstrated that both compounds have anti- Campylobacter activity, inhibited in vitro biofilm formation and promoted biofilm dispersion even at sub-MIC concentrations and interfered with the QS system through the inhibition of violacein production. Moreover, the essential oil and linalool were shown to have radical scavenging properties and lipid peroxidation inhibition ability which could make them potential alternatives to synthetic antioxidants. In sum, our results demonstrated the antibacterial, anti-biofilm, anti-QS and antioxidant potentials of the coriander essential oil and its major compound, linalool, suggesting that they could be used in the food industry to enhance shelf life of food products and increase food safety without requiring chemical additives or preservatives.
- O Laboratório de Proteómica do Instituto Ricardo JorgePublication . Penque, DeborahLaboratório de Proteómica do Instituto Ricardo Jorge - Missão: 1) Desenvolver uma plataforma I&D e Inovação (IDI) de proteómica para validação e implementação de biomarcadores já existentes e/ou descoberta de novos biomarcadores de diagnóstico, diagnóstico, prognóstico prognóstico e monitorização monitorização de doenças, doenças, ou ainda como alvos de novas abordagens terapêuticas; 2) Prestar serviços de identificação/caracterização de proteínas pela proteómica; 3) Contribuir para o desenvolvimento da proteómica no nosso país (promoção/realização de cursos/estágios/conferências, networking) na área da proteómica.