Browsing by Author "Vinagre, Elsa"
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- Avaliação Externa da Qualidade em Serologia da Rubéola, PNAEQ (2015-2017)Publication . Correia, Helena; Cardoso, Ana; Pereira, Edna; Ventura, Catarina; Viegas, Sílvia; Vinagre, Elsa; Palminha, Paula; Faria, Ana PaulaA Rubéola é uma infeção viral aguda e contagiosa que pode ser prevenida pela vacinação. A infeção pelo vírus da Rubéola em crianças e adultos provoca sintomas como febre ligeira e exantema. No entanto, a infeção durante a gravidez, especialmente durante o primeiro trimestre, pode provocar aborto, morte fetal, nado-morto, ou crianças com malformações congénitas. Em Portugal, a vacina contra a Rubéola foi introduzida no Plano Nacional de Vacinação (PNV) em 1982 e nos últimos 7 anos foram notificados 3 casos de rubéola congénita, dois dos quais importados e um autóctone. Todos os casos resultaram de infeções sintomáticas em mulheres não vacinadas. O Programa Nacional de Avaliação Externa da Qualidade (PNAEQ) implementou em 1994 o programa de serologia para diagnóstico laboratorial da Rubéola e conta com peritos na área. O objetivo deste trabalho é avaliar o desempenho dos laboratórios participantes no PNAEQ na determinação de IgG, IgM e avidez da IgG para rubéola no período 2015 a 2017.
- Challenging measles case definition: three measles outbreaks in three Health Regions of Portugal, February to April 2018Publication . Augusto, Gonçalo Figueiredo; Cruz, Diogo; Silva, Andreia; Pereira, Natália; Aguiar, Bárbara; Leça, Ana; Serrada, Elisabete; Valente, Paula; Fernandes, Teresa; Guerra, Fernando; Palminha, Paula; Vinagre, Elsa; Lopo, Sílvia; Cordeiro, Rita; Sáez-López, Emma; Neto, Maria; Nogueira, Paulo Jorge; Freitas, GraçaWe report three simultaneous measles outbreaks with 112 confirmed cases in three Health Regions of Portugal, from February to April 2018. The mean age of cases was 30 years, 79% worked in a healthcare setting and 87% were vaccinated. Genotype B3 was identified in 84 cases from the three outbreaks. Primary cases in each outbreak were imported. Several cases presented with modified measles, highlighting the importance of rethinking the measles case definition for vaccinated cases.
- Citomegalovírus: análise retrospetiva de casos suspeitos de infeção do sistema nervoso central, diagnosticados entre 2010 e 2014Publication . Lopo, Sílvia; Reis, Tânia; Palminha, Paula; Vinagre, Elsa; Furtado, CristinaEste estudo tem como objetivo descrever as características demográficas e o quadro clínico e imunitário de doentes com suspeita de infeção viral neurotrópica e analisar a frequência das infeções por CMV nas patologias do SNC, cujo diagnóstico foi confirmado no Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA) entre janeiro de 2010 e abril de 2014.
- CMV and HCV infections in HIV/non-HIV mothers and newborns: prevalence, frequency and risk factorsPublication . Lopo, Sílvia; Pereira, Maria Amável; Mendonça, Joana; Vinagre, Elsa; Reis, Tânia; Cordeiro, Dora; Almeida, Catarina; Água-Doce, Ivone; Manita, Carla; Palminha, Paula; Pádua, Elizabeth; Paixão, Maria Teresa; Carreiro, Helena; Barroso, Rosalina; Campos, Teresa; Marques, TâniaThe incidence of HIV infections in gestational age is an important Public Health issue as are concerns about co-infection with opportunistic viruses, such as CMV/HCV. Several authors refer higher ratios of congenital CMV infection in children born to HIV infected mother than in uninfected. In the case of HCV, perinatal transmission increases in cases of mothers co-infected with HIV. Aims:To study CMV/HCV infection/co-infection in HIV/non-HIV women and their newborns between 2006-2010, according to epidemiological, laboratory and clinical data; to evaluate frequency of CMV/HIV/HCV maternal-fetal transmission and analyse risk factors for infections. Methods:Plasma and/or urine of 137 HIV and 140 non-HIV women, attending a Lisbon Hospital and their 140 newborns were analysed at NIH. HIV-1 and/or HIV-2 proviral DNA nested-PCR was performed on HIV mothers and their newborn’s plasma. Maternal plasma was screened for CMV and HCV antibodies; RNA determination, genotyping and viral load were performed on women with HCV antibodies, their newborn’s plasma was also screened for HCV. Newborn’s urine was inoculated for CMV detection. Data analysis was performed using SPSS 17.0 and Fisher's exact test. Results:HIV1 vertical transmission was diagnosed in 3/140(2.1%) cases. CMV congenital infection was diagnosed in 4(2.9%) newborns from HIV women and no congenital CMV infection was diagnosed in newborns from non-HIV women. 2/137(1.5%) HIV women and 14/140(10.0%) non-HIV women were CMV seronegative. HCV infection was detected in 6(4.4%) HIV women; all had HCV positive viral load; different genotypes were found. One case of HCV perinatal transmission was diagnosed. No HCV antibodies were found in non-HIV women. No children were HIV/HCV or CMV/HCV coinfected but 2 were HIV/CMV coinfected. There is evidence of significant statistical associations with race/ethnicity and time of pregnancy. Conclusion:In this study HIV women had higher CMV/HCV antibody prevalence and frequency of maternal-fetal transmission than non-HIV women. 2/137 HIV seronegative newborns and 2/3 HIV newborns were CMV congenitally infected; this difference should be further studied, as the consequences of CMV/HCV infections may become increasingly serious and complex in the presence of HIV. This specific group is not representative of the Portuguese infected women, nevertheless the significant risk factors found and other risk factors studied without strong associations should be considered in larger studies.
- Diagnóstico laboratorial do sarampo em Portugal, 2011-2013Publication . Palminha, Paula; Vinagre, Elsa; Cordeiro, Rita; Ribeiro, Carlos; Roque, CarlaObjetivo: Este estudo tem como objetivo descrever os casos prováveis de sarampo enviados ao INSA para confirmação laboratorial entre 2011 e 2013 em Portugal.
- Infeção por parvovírus B19 durante a gravidez: análise retrospetiva de casos suspeitos diagnosticados no INSA (2009-2012)Publication . Lopo, Sílvia; Reis, Tânia; Palminha, Paula; Vinagre, Elsa; Gargaté, Maria João
- Parotidite epidémica em adolescentes vacinados entre 2012-2013Publication . Palminha, Paula; Vinagre, Elsa; Cordeiro, Eugénio; Ribeiro, Carlos; Roque, Carla
- Report of simultaneous measles outbreaks in two different health regions in Portugal, February to May 2017: lessons learnt and upcoming challengesPublication . Augusto, Gonçalo Figueiredo; Silva, Andreia; Pereira, Natália; Fernandes, Teresa; Leça, Ana; Valente, Paula; Calé, Etelvina; Aguiar, Bárbara Andreia; Martins, António; Palminha, Paula; Vinagre, Elsa; Cordeiro, Rita; Lopo, Sílvia; Nogueira, Paulo JorgeIn Portugal, measles vaccination coverage and population immunity are high, and no endemic measles cases had been reported since 2004. The World Health Organization classified measles as eliminated in the country in 2015 and 2016, based on data from the previous 3 years. However, in a context of increasing incidence in several European countries in 2016 and 2017, Portugal experienced two simultaneous measles outbreaks with a total of 27 laboratory-confirmed cases (0.3 cases/100,000 population) in two health regions between February and May 2017. Nineteen cases (70.1%) were adults, of whom 12 were healthcare workers. Overall, 17 cases (63.0%) were not vaccinated, of whom five were infants younger than 12 months of age. One unvaccinated teenager died. Genotype B3 was identified in 14 cases from both regions. Measles virus sequencing identified different possible origins of the virus in each region affected. Although measles transmission was stopped in less than 2 months from the first case being notified, these outbreaks represent an opportunity to reinforce awareness of measles diagnosis. We highlight the intensity of the control measures taken and their impact on the rapid control of the outbreaks and also the fact that high vaccination coverage was crucial to stop transmission.
- Rubéola congénita em Portugal entre 2009 e 2015Publication . Palminha, Paula; Vinagre, Elsa; Ribeiro, Carlos; Lourenço, Teresa; Roque, CarlaObjetivo: Analisar os resultados do diagnóstico laboratorial de casos suspeitos de rubéola congénita recebidos no Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA) entre 2009 e 2015, ao abrigo do Programa de Eliminação do Sarampo, da Rubéola e da Rubéola Congénita na Região Europeia da Organização Mundial da Saúde (OMS).
- Sarampo em Portugal: a caminho da eliminaçãoPublication . Palminha, Paula; Vinagre, Elsa; Cordeiro, Rita; Ribeiro, Carlos; Roque, Carla