Percorrer por autor "Santos, Madalena"
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- Environment and Health in Children Day Care CentresPublication . Neuparth, Nuno; Papoila, Ana Luísa; Aelenei, Daniel; Cano, Manuela; Paixão, Paulo; Viegas, João; Martins, Pedro; Araújo Martins, José; Leiria Pinto, Paula; Caires, Iolanda; Pedro, Catarina; Nogueira, Susana; Mendes, Ana; Aguiar, Fátima; Teixeira, João Paulo; Proença, Carmo; Piedade, Cátia; Santos, Madalena; Silvestre, Maria José; Brum, Laura; Nunes, Baltazar; Guiomar, Raquel; Curran, Martin D.; Carvalho, Ana; Marques, Teresa; Virella, Daniel; Alves, Marta; Marques, João; Rosado-Pinto, José; Neuparth, Nuno; Aelenei,Daniel; Caires, Iolanda; Teixeira, João Paulo; Viegas, João; Cano, Manuela; Pinto, Paula LeiriaThis project addresses a set of common clinical problems in the context of children attending day care centres. It is common sense that children get sick more often as soon as they start attending a day care centre on a daily basis and this is particularly true for some groups at risk, as wheezing infants and wheezing pre-school children. Concerning this, some questions remain unclear: 1. The role of indoor air quality - what is the health impact of indoor air environment (including indoor pollutants, house dust mite, temperature and humidity) in wheezing children? 2. The role of virus infections - We don’t know the real role of virus infections in respiratory conditions at day care centre level. There is a lack of information concerning how indoor air environment influence virus infections. 3. The role of building ventilation - what is the impact of building ventilation in the health of wheezing and non-wheezing children? How is ventilation affecting indoor air quality? How is ventilation of day care centres affected by the structure of the buildings? 4. Social impact of this study - what should be the recommendations to improve IAQ? What is new in this project is the collaboration of a health team (medical doctors and other health professionals) with environment specialists, mechanical, civil engineers, epidemiologists and statisticians.
- Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin LymphomaPublication . Borges, Vítor; Isidro, Joana; Cunha, Mário; Cochicho, Daniela; Martins, Luís; Banha, Luís; Figueiredo, Margarida; Rebelo, Leonor; Trindade, Maria Céu; Duarte, Sílvia; Vieira, Luís; Alves, Maria João; Costa, Inês; Guiomar, Raquel; Santos, Madalena; Cortê-Real, Rita; Dias, André; Póvoas, Diana; Cabo, João; Figueiredo, Carlos; Manata, Maria José; Maltez, Fernando; Gomes da Silva, Maria; Gomes, João PauloRecent studies have shown that persistent SARS-CoV-2 infections in immunocompromised patients can trigger the accumulation of an unusual high number of mutations with potential relevance at both biological and epidemiological levels. Here, we report a case of an immunocompromised patient (non-Hodgkin lymphoma patient under immunosuppressive therapy) with a persistent SARS-CoV-2 infection (marked by intermittent positivity) over at least 6 months. Viral genome sequencing was performed at days 1, 164, and 171 to evaluate SARS-CoV-2 evolution. Among the 15 single-nucleotide polymorphisms (SNPs) (11 leading to amino acid alterations) and 3 deletions accumulated during this long-term infection, four amino acid changes (V3G, S50L, N87S, and A222V) and two deletions (18-30del and 141-144del) occurred in the virus Spike protein. Although no convalescent plasma therapy was administered, some of the detected mutations have been independently reported in other chronically infected individuals, which supports a scenario of convergent adaptive evolution. This study shows that it is of the utmost relevance to monitor the SARS-CoV-2 evolution in immunocompromised individuals, not only to identify novel potentially adaptive mutations, but also to mitigate the risk of introducing "hyper-evolved" variants in the community.
- Respiratory infections in elderly people: Viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014Publication . Chasqueira, Maria-Jesus; Paixão, Paulo; Rodrigues, Maria-Lúcia; Piedade, Cátia; Caires, Iolanda; Palmeiro, Teresa; Botelho, Maria-Amalia; Santos, Madalena; Curran, Martin; Guiomar, Raquel; Pechirra, Pedro; Costa, Inês; Papoila, Ana; Alves, Marta; Neuparth, NunoObjective: The aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents. Methods: Nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1–4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases. Results: In total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n = 53), followed by influenza A(H3) (n = 19) and HBoV (n = 14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. “Age”, “HMPV” and “Respiratory disease” showed an association with severe infection. Conclusions: In this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.