Percorrer por autor "Ribeiro, A.R."
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- High throughput toxicity screening and intracellular detection of nanomaterialsPublication . Collins, A.R.; Annangi, B.; Rubio, L.; Marcos, R.; Dorn, M.; Merker, C.; Estrela-Lopis, I.; Cimpan, M.R.; Ibrahim, M.; Cimpan, E.; Ostermann, M.; Sauter, A.; Yamani, N.E.; Shaposhnikov, S.; Chevillard, S.; Paget, V.; Grall, R.; Delic, J.; de-Cerio, F.G.; Suarez-Merino, B.; Fessard, V.; Hogeveen, K.N.; Fjellsbø, L.M.; Pran, E.R.; Brzicova, T.; Topinka, J.; Silva, M.J.; Leite, P.E.; Ribeiro, A.R.; Granjeiro, J.M.; Grafström, R.; Prina-Mello, A.; Dusinska, M.With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical dilemmas associated with animal research. Data are needed for developing intelligent testing strategies for risk assessment of NMs, based on grouping and read-across approaches. The adoption of high throughput screening (HTS) and high content analysis (HCA) for NM toxicity testing allows the testing of numerous materials at different concentrations and on different types of cells, reduces the effect of inter-experimental variation, and makes substantial savings in time and cost.
- Towards a nanospecific approach for risk assessment.Publication . Dekkers, S.; Oomen, A.G.; Bleeker, E.A.; Vandebriel, RJ..; Micheletti, C.; Cabellos, J.; Janer, G.; Fuentes, N.; Vázquez-Campos, S.; Borges, T.; Silva, M.J.; Prina-Mello, A.; Movia, D.; Nesslany, F.; Ribeiro, A.R.; Leite, P.E.; Groenewold, M.; Cassee, F.R.; Sips, A.J.; Dijkzeul, A.; van Teunenbroek, T.; Wijnhoven, S.W.In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard assessment that are most likely to be influenced by the nanospecific properties of the material under assessment are identified. These aspects are summarised in six elements, which play a key role in the strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and immunotoxicity. With the current approach it is possible to identify those situations where the use of nanospecific grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the generation of the type of data that is needed for scientific justification, which may lead to regulatory acceptance of nanospecific applications of these tools.