Browsing by Author "Ramalheira, J.E.D.P."
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- MiR-134 serum expression in Mesial Temporal Lobe Epilepsy patientsPublication . Leal, B.; Rodrigues, D.; Carvalho, C.; Ferreira, R.; Chaves, J.M.M.; Bettencourt, A.; Freitas, J.; Lopes, J. M.C.F.; Ramalheira, J.E.D.P.; Martins da Silva, A.; Costa, P.P.; Martins da Silva, B.Background and aims: Several experimental and clinical studies have suggested that microRNAs (miRNAs) could be potential epilepsy biomarkers. Nowadays, research has been focused in miR-134, a brain-specific miRNA that plays important roles in dendritic spine development and neuronal structure regulation. An upregulation of miR-134 has been reported both in brain tissue of experimental models (Jimenez-Mateos 2012) and plasma from epileptic patients (Sun 2017). It has also been observed that some anti-seizure drugs down regulate mir-134 plasmatic levels (Sun 2017) highlighting the role of this miRNA in epileptogenesis. Our aim was to quantify miR-134 serum levels in a cohort of Mesial Temporal Lobe Epilepsy (MTLE) patients and correlate with clinical characteristics such as drug response.
- Preliminar study on BDNF regulation by DNA methylation in Mesial Temporal Lobe EpilepsyPublication . Ferreira, R.; Leal, B.; Chaves, J.M.M.; Carvalho, C.; Bettencourt, A.; Freitas, J.; Ramalheira, J.E.D.P.; Lopes, J.M.C.F.; Martins da Silva, A.; Costa, P.P.; Silva, B.Background and aims: Brain-derived neurotrophic factor (BDNF) is a neurothrophin associated with a wide range of neurophysiological processes, such as neurogenesis, gliogenesis, synaptogenesis and neuroprotection. BDNF has been described as overexpressed in hippocampus of both animal models and Mesial Temporal Lobe Epilepsy (MTLE) patients. Gene expression may be modulated by DNA methylation of the respective promoter regions. We sought to analyze, the DNA methylation of the BDNF exon I promoter, a region associated with neuronal imbalance