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MiR-134 serum expression in Mesial Temporal Lobe Epilepsy patients

2018-06Documento de conferência Acesso restrito
http://hdl.handle.net/10400.18/6355
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Autores

Leal, B.
Rodrigues, D.
Carvalho, C.
Ferreira, R.
Chaves, J.M.M.
Bettencourt, A.
Freitas, J.
Lopes, J. M.C.F.
Ramalheira, J.E.D.P.
Martins da Silva, A.

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Resumo(s)

Background and aims: Several experimental and clinical studies have suggested that microRNAs (miRNAs) could be potential epilepsy biomarkers. Nowadays, research has been focused in miR-134, a brain-specific miRNA that plays important roles in dendritic spine development and neuronal structure regulation. An upregulation of miR-134 has been reported both in brain tissue of experimental models (Jimenez-Mateos 2012) and plasma from epileptic patients (Sun 2017). It has also been observed that some anti-seizure drugs down regulate mir-134 plasmatic levels (Sun 2017) highlighting the role of this miRNA in epileptogenesis. Our aim was to quantify miR-134 serum levels in a cohort of Mesial Temporal Lobe Epilepsy (MTLE) patients and correlate with clinical characteristics such as drug response.

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Epilepsy Doenças Genéticas

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http://hdl.handle.net/10400.18/6355

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DGH - Apresentações orais em encontros internacionais

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