Publication
MiR-134 serum expression in Mesial Temporal Lobe Epilepsy patients
| dc.contributor.author | Leal, B. | |
| dc.contributor.author | Rodrigues, D. | |
| dc.contributor.author | Carvalho, C. | |
| dc.contributor.author | Ferreira, R. | |
| dc.contributor.author | Chaves, J.M.M. | |
| dc.contributor.author | Bettencourt, A. | |
| dc.contributor.author | Freitas, J. | |
| dc.contributor.author | Lopes, J. M.C.F. | |
| dc.contributor.author | Ramalheira, J.E.D.P. | |
| dc.contributor.author | Martins da Silva, A. | |
| dc.contributor.author | Costa, P.P. | |
| dc.contributor.author | Martins da Silva, B. | |
| dc.date.accessioned | 2019-04-01T15:54:51Z | |
| dc.date.available | 2019-04-01T15:54:51Z | |
| dc.date.issued | 2018-06 | |
| dc.description.abstract | Background and aims: Several experimental and clinical studies have suggested that microRNAs (miRNAs) could be potential epilepsy biomarkers. Nowadays, research has been focused in miR-134, a brain-specific miRNA that plays important roles in dendritic spine development and neuronal structure regulation. An upregulation of miR-134 has been reported both in brain tissue of experimental models (Jimenez-Mateos 2012) and plasma from epileptic patients (Sun 2017). It has also been observed that some anti-seizure drugs down regulate mir-134 plasmatic levels (Sun 2017) highlighting the role of this miRNA in epileptogenesis. Our aim was to quantify miR-134 serum levels in a cohort of Mesial Temporal Lobe Epilepsy (MTLE) patients and correlate with clinical characteristics such as drug response. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6355 | |
| dc.language.iso | eng | pt_PT |
| dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.13698 | pt_PT |
| dc.subject | Epilepsy | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.title | MiR-134 serum expression in Mesial Temporal Lobe Epilepsy patients | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | 4th Congress of the European Academy of Neurology, 16-19 June 2018 | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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