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Preliminar study on BDNF regulation by DNA methylation in Mesial Temporal Lobe Epilepsy

2018-06Conference object Restricted access
http://hdl.handle.net/10400.18/6356
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Authors

Ferreira, R.
Leal, B.
Chaves, J.M.M.
Carvalho, C.
Bettencourt, A.
Freitas, J.
Ramalheira, J.E.D.P.
Lopes, J.M.C.F.
Martins da Silva, A.
Costa, P.P.

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Abstract(s)

Background and aims: Brain-derived neurotrophic factor (BDNF) is a neurothrophin associated with a wide range of neurophysiological processes, such as neurogenesis, gliogenesis, synaptogenesis and neuroprotection. BDNF has been described as overexpressed in hippocampus of both animal models and Mesial Temporal Lobe Epilepsy (MTLE) patients. Gene expression may be modulated by DNA methylation of the respective promoter regions. We sought to analyze, the DNA methylation of the BDNF exon I promoter, a region associated with neuronal imbalance

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Keywords

Brain-derived Neurotrophic Factor Doenças Genéticas

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http://hdl.handle.net/10400.18/6356

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Citation

uropean Journal of Neurology. 2018;25(Suppl. 2):226

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