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Preliminar study on BDNF regulation by DNA methylation in Mesial Temporal Lobe Epilepsy

2018-06Documento de conferência Acesso restrito
http://hdl.handle.net/10400.18/6356
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Autores

Ferreira, R.
Leal, B.
Chaves, J.M.M.
Carvalho, C.
Bettencourt, A.
Freitas, J.
Ramalheira, J.E.D.P.
Lopes, J.M.C.F.
Martins da Silva, A.
Costa, P.P.

Orientador(es)

Resumo(s)

Background and aims: Brain-derived neurotrophic factor (BDNF) is a neurothrophin associated with a wide range of neurophysiological processes, such as neurogenesis, gliogenesis, synaptogenesis and neuroprotection. BDNF has been described as overexpressed in hippocampus of both animal models and Mesial Temporal Lobe Epilepsy (MTLE) patients. Gene expression may be modulated by DNA methylation of the respective promoter regions. We sought to analyze, the DNA methylation of the BDNF exon I promoter, a region associated with neuronal imbalance

Descrição

Palavras-chave

Brain-derived Neurotrophic Factor Doenças Genéticas

URI

http://hdl.handle.net/10400.18/6356

Contexto Educativo

Citação

uropean Journal of Neurology. 2018;25(Suppl. 2):226

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Fascículo

Editora

Coleções

DGH - Posters/abstracts em congressos internacionais

Licença CC