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Preliminar study on BDNF regulation by DNA methylation in Mesial Temporal Lobe Epilepsy

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dc.contributor.authorFerreira, R.
dc.contributor.authorLeal, B.
dc.contributor.authorChaves, J.M.M.
dc.contributor.authorCarvalho, C.
dc.contributor.authorBettencourt, A.
dc.contributor.authorFreitas, J.
dc.contributor.authorRamalheira, J.E.D.P.
dc.contributor.authorLopes, J.M.C.F.
dc.contributor.authorMartins da Silva, A.
dc.contributor.authorCosta, P.P.
dc.contributor.authorSilva, B.
dc.date.accessioned2019-04-01T16:17:06Z
dc.date.available2019-04-01T16:17:06Z
dc.date.issued2018-06
dc.description.abstractBackground and aims: Brain-derived neurotrophic factor (BDNF) is a neurothrophin associated with a wide range of neurophysiological processes, such as neurogenesis, gliogenesis, synaptogenesis and neuroprotection. BDNF has been described as overexpressed in hippocampus of both animal models and Mesial Temporal Lobe Epilepsy (MTLE) patients. Gene expression may be modulated by DNA methylation of the respective promoter regions. We sought to analyze, the DNA methylation of the BDNF exon I promoter, a region associated with neuronal imbalancept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationuropean Journal of Neurology. 2018;25(Suppl. 2):226pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6356
dc.language.isoengpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.13699pt_PT
dc.subjectBrain-derived Neurotrophic Factorpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titlePreliminar study on BDNF regulation by DNA methylation in Mesial Temporal Lobe Epilepsypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title4th Congress of the European Academy of Neurology, 16-19 June 2018pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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