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Browsing by Author "Macedo, R."

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  • Poly-resistant tuberculosis outbreak in Northern Portugal: a nine year tale
    Publication . Gomes, B.; Molina-Correa, G.; Neves-Reina, L.; Oliveira, A.C.; Macedo, R.; Carvalho, C.; Correia, A.M.
    Extract: In 2017, the notification rate of tuberculosis in the Northern Region of Portugal was 21.1 cases per 100 000 inhabitants. According to the National Tuberculosis Programme Surveillance System (SVIG-TB), poly-resistance to isoniazid and streptomycin (PR-HS) represented 2.6–5% of the cases notified in the Northern Region between 2009 and 2017 Although they represent a relatively low proportion of cases in Portugal, poly-resistances such as PR-HS are precursors to multidrug resistance and, consequently, should be closely monitored.
    2020-12Journal article Open access Show more
  • Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
    Publication . Mendes-Bastos, P.; Macedo, R.; Duarte, R.
    Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin has been suggested as a possible treatment regimen. Five studies have evaluated the efficacy of this combination, the majority of which reported the use of clindamycin 600 mg daily + rifampicin 600 mg daily with an average length of 10 consecutive weeks.1–5 In three out of four studies, 10-week follow-up yielded complete remission in 32% (32/116) of patients1–3; in another study, a 1-year follow-up demonstrated sustained efficacy in only seven of 26 patients.5 Scheinfeld has discussed why rifampicin is a key drug in the treatment of HS, pointing out its antibacterial and anti-inflammatory effects, its activity on bacterial biofilms, its effect against granulomas and its immunomodulatory properties on neutrophils. (...)
    2017-10Journal article Restricted access Show more