Browsing by Author "Cortez-Pinto, Helena"
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- Good correlation between plasma cytokeratin-18 and controlled attenuation parameter (CAP) in healthy populationPublication . Carvalhana, Sofia; Leitão, Jorge; Alves, Catarina; Bourbon, Mafalda; Cortez-Pinto, HelenaIntroduction: Liver steatosis measurement by controlled attenuation parameter (CAP) is a noninvasive method for diagnosing steatosis1. Plasma caspase-generated cytokeratin-18 fragments (CK-18) have been proposed as a non-invasive alternative for the diagnosis of NAFLD, especially NASH2. Aims: compare CK-18 serum levels in apparently healthy individuals with and without steatosis.
- HCV and HBV prevalence in the population: Large disparity between Hepatitis C in the general population, comparing with high risk groupsPublication . Carvalhana, Sofia; Pinto, Rui; Leitão, Jorge; Silva, Ana Paula; Alves, Catarina; Bourbon, Mafalda; Carvalho, Armando; Cortez-Pinto, HelenaIntroduction: The burden of hepatitis B and C infections around the world is high1,2; With the upcoming very effective treatments for hepatitis C and the rather effective treatments for hepatitis B, there is urge to identify these patients and estimate their prevalence in each country.
- Hepatitis B serologic markers after 14 years of universal new-born vaccinationPublication . Carvalhana, Sofia; Pinto, Rui; Leitão, Jorge; Silva, Ana Paula; Alves, Catarina; Bourbon, Mafalda; Carvalho, Armando; Cortez-Pinto, HelenaIntroduction: The burden of hepatitis B infection around the world is very high1; Hepatitis B National Vaccination Programe in Portugal: - all adolescents since 1995 - all new-borns in the year 2000. Aim: evaluate how it affected serological markers of hepatitis B in the general population and in high-risk group.
- No Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Steatosis. A Study on the Portuguese General PopulationPublication . Leitão, Jorge; Carvalhana, Sofia; Silva, Ana Paula; Velasco, Francisco; Medeiros, Isabel; Alves, Ana Catarina; Bourbon, Mafalda; Oliveiros, Bárbara; Carvalho, Armando; Cortez-Pinto, HelenaIntroduction and aims: Nonalcoholic fatty liver disease (NAFLD) has become highly prevalent, paralleling the pandemic of obesity and diabetes, and represents an important burden. Nutrition knowledge is fundamental, in prevention, evolution and treatment of NAFLD. Association of low serum levels of vitamin D (VD) with several diseases, including NAFLD, has been emphasized in the last decade. We evaluated how serum levels of VD correlate with the presence of hepatic steatosis, and VD intake, in a random sample of the Portuguese adult population. Methods: Participants underwent a dietary intake inquiry, using a semi-quantitative food frequency questionnaire representative of the usual intake over the previous year. Anthropometric measures, blood tests and ultrasound were done. Hepatic steatosis was quantified according to Hamaguchi's ultrasonographic score (steatosis defined by a score ≥ 2). Results: We recruited 789 adult individuals, 416 males (52.7%), mean age of 49.9 ± 17.0 years (18-79). Prevalence of hepatic steatosis was 35.5%, and after exclusion of excessive alcohol consumption, 28.0%. Mean VD serum levels were 26.0 ± 9.8 ng/ml and 68.4% participants had serum VD levels below 30 ng/ml. Mean serum levels of VD were not significantly different between participants with steatosis vs. no steatosis: 25.2±8.7 vs. 26.4±10.3 ng/ml, respectively (p=0.071). There was no correlation between VD serum levels and VD intake, measured by the FFQ, r=0.075 (p= 0.383). Conclusions: In spite of a high prevalence rate, there was no evidence that decreased VD serum levels were associated with hepatic steatosis. No significant correlation was found between VD dietary ingestion and VD serum levels.
- “Normal” controlled attenuation parameter (CAP) values: a population-based study of healthy subjectsPublication . Carvalhana, Sofia; Leitão, Jorge; Alves, Catarina; Bourbon, Mafalda; Cortez-Pinto, HelenaIntroduction: Liver steatosis measurement by controlled attenuation parameter (CAP) is a noninvasive method for diagnosing steatosis1. The normal range of CAP values needs to be explored in clinical and anthropometrically diverse healthy subjects. Aims: define the normal range of CAP values in healthy subjects and evaluate the associated factors.
- Prevalence of hepatic steatosis in the general Portuguese population: using fatty liver index (FLI) and ultrasoundPublication . Carvalhana, Sofia; Leitão, Jorge; Silva, Ana Paula; Alves, Catarina; Bourbon, Mafalda; Carvalho, Armando; Cortez-Pinto, HelenaIntrodution: The fatty liver index (FLI)1 has been used as a noninvasive measure of hepatic steatosis (HS), but has not been widely validated and not examined in the Portuguese population. According to Bedogni FLI < 30 rules out and FLI ≥ 60 rules in HS1. Aims:- Estimate the prevalence of HS in the Portuguese adult population by FLI and correlate with the ultrasound findings; - Validate FLI for prediction of fatty liver in the Portuguese population.