DEP - Apresentações orais em encontros internacionais
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- Congenital Anomalies and Cerebral Palsy: Data from the Portuguese Cerebral Palsy Surveillance ProgramPublication . Cadete, Ana; Folha, Teresa; Braz, Paula; Calado, Eulália; Alvarelhão, Joaquim; Virella, DanielBackground and Objectives: Attention was recently drawn to the association of congenital anomalies (CA) with severity and complexity of cerebral palsy (CP). Evidence of this association is presented. Participants-Methods: The Portuguese National Surveillance of Cerebral Palsy (PNSCP) registers data of 5-to-8-year-old children with CP, born since 2001. The PNSCP follows the Surveillance of Cerebral Palsy in Europe (SCPE) common database protocol. Data were cross-referenced with the Portuguese National Registry of Congenital Anomalies. Children born between 2001-2015, notified until September 2024, were analyzed. CA were characterized according to ICD-10, following the EUROCAT criteria. Associations between the clinical forms of CP, complexity indicators and the presence of CA were explored. Results: Of 2251 registered children, 603 (27%; 95%CI 24.9-28.6) had at least one CA recorded; 228 children had multiple CA (10%; 95%CI 8.9-11.4). CA of the nervous system Q00-Q07 (CANS) are the most frequent (16%; 95%CI 14.9-18.0), followed by CA of the circulatory system Q20-Q28 (CACS) (4.9%; 95%CI 4.1-59). The odds of having at least one indicator of CP complexity increases by 2.6 times when having a CA (OR 2.6; 95%CI 2.01-3.48); slightly higher if a CANS exists (2.9; 95%CI 2.06-4,21), and slightly lower if a CACS exists (1.6; 95%CI 0.98-2.83). Conclusion: The prevalence of CA in children with CP is much higher than in the general population and increases the odds for greater severity and/or complexity of CP. The odds seems to be higher in the presence of CANS. This should be considered when assessing the prognosis and planning intervention.
- European Deprivation Index and children with Cerebral Palsy: Data from the Portuguese Cerebral Palsy Surveillance ProgramPublication . Folha, Teresa; Cadete, Ana; Sousa-Uva, Mafalda; Aniceto, Carlos; Braz, Paula; Calado, Eulália; Alvarelhão, Joaquim; Virella, DanielIntroduction: Socioeconomic inequalities have been associated with the severity of cerebral palsy (CP). The European Deprivation Index (EDI) accounts for aggregated ecological effects not yet identified. We describe the association between complexity and etiology of CP and a proxy for socioeconomic inequalities in Portugal. Participants and Methods: The Portuguese National Surveillance of Cerebral Palsy (PNSCP) collects data of 5-to-8-year-old children with CP, born since 2001, following the Surveillance of Cerebral Palsy in Europe (SCPE) datacollection protocol. Official live-birth (LB) statistics and data from children with CP born between 2001-2015, notified until September 2024, were analysed according to the area-level socioeconomic deprivation at birth, using the Portuguese version of the EDI (EDI-PT), categorized in tertiles and measured at municipal level. The CP severity/complexity was classified using the Cerebral Palsy Complexity-Scale (CPC-Scale). Associations were estimated by the odds ratio (OR) with a 95% confidence interval (95%CI). Results: 2,410 registered children with CP were classified according to tertiles of EDI-PT: 481 children in the 1st tertile (20%-CP vs 23%-LB); 591 in the 2nd (25%-CP vs 33%-LB) and 1,338 in the 3d (55%-CP vs 44% LB). Significant associations were observed between the 3rd tertile of EDI-PT and both post-neonatal causes of CP (OR 2.365; CI 1.408, 4.175) and the complexity of CP (OR 1.355; CI 1.029, 1.782). Conclusion: Area-level socioeconomic disadvantage at birth appears to have a positive effect on the odds for more severe/complex CP and the occurrence of post-neonatal cases of CP. Further investigation is needed to better understand these associations.
- Postneonatal Cerebral Palsy according to the new surveillance of Cerebral Palsy in Europe Classification: Data from the Portuguese Cerebral Palsy Surveillance ProgramPublication . Cadete, Ana; Folha, Teresa; Calado, Eulália; Alvarelhão, Joaquim; Gouveia, Rosa; Virella, DanielBackground and Objectives: The Portuguese National Surveillance of Cerebral Palsy Program (PNSCPP) registers clinical, epidemiological and functional data of children with cerebral palsy(CP) at 5-8 year old, born in the 21 st century, The Surveillance of Cerebral Palsy in Europe (SCPE) recently published the classification of primary events contributing to postneonatal cerebral palsy (CEC-PNCP) in whose validation process the PCPSP contributed with part of the cases reported. We propose to analyze all portugueses cases of post-neonatal cause, according to the SCPE (CPEC-PNCP). Participants and Methods: The PNSCPP uses multiple sources, following the common Surveillance of Cerebral Palsy in Europe (SCPE) protocol, including CP definition and classification, neuroimaging and associated impairments. Children with post-neonatal cause (PNCP) born between 2001-2015 and reported to the PVNPC between 2006-2024 at living in Portugal at 5-8 years were analysed acording the CEC-PNCP. Results: Were analysed 203 (9%) children with PNCP from a total of 2276. Age of injury between 1-59th month of life, almost (80%) up to 24th months. Applying the CPEC-PNCP, were classified according to the categories: A-Infections (CA-I) 84 cases (41%); 22 (11%) B-Traumatic Brain Injury (CBI-T); 44 (22%); C-Injury related to medical procedure (CC-IRMP), 30 (15%) D-Stroke (CD-CVA), 14 (7%); E-Hypoxic Brain Damaging (CE-HBD); 9 (4%) in class F-Miscellaneous (CF-M). Spastic Cerebral Palsy (SCP) was the most frequently recorded clinical type, ranging from 100% in CD-CVA to 84.1% in CA-I. Dyskinetic Cerebral Palsy (DCP) was more common in the CE- HBD (15.4%) and CA-I (13.4%), and Ataxic Cerebral Palsy (ACP) in CF-M (11.1%) (p0.102). The presence of any congenital anomaly (CA) was confirmed in 47/197 children (23.9%). CC- IRMP registed the highest proportion of CA (65.1%), followed by CD-CVA (33.3%) and CE- HBD (21.4%). The cardiac CA subtype (ICD-10-Q2) registed 46.5% in CC- IRMP and 0% in CB-TBI and CF-M. The class with the best functional record was CB-TBI (GMF-I-II: 63.7%); (BFMF-I-II 57.1%); The worst functional was CE- HBD (GMF-III-IV-V 90.9%) and (BFMF-III-IV-V 100%). Associated morbidity and school inclusion varied among the different categories. Conclusion: Children with CP-PNN differ greatly according to the CPEC-PNCP in terms of clinical type, functional skills. This classification allows a better characterization of the primary event contributing to post-neonatal etiopathological process, a better understanding and action in the rehabilitation and inclusion processes and provide an opportunity for preventive measures to be implemented.
