A carregar...
Publicação
Ultra-low coverage nanopore sequencing identifies thousands of structural variants in a tumor genome
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 51.83 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Objectives/Context: Nanopore sequencing is a recent technology which allows direct sequencing of DNA. It uses an ionic current to move DNA strands through nanopores embedded in an electrically-resistant membrane. The changes in nanopore signals are recorded by an ASIC chip placed below the membrane and translated into a specific base sequence. Nanopore sequencing provides a better alternative than short-read technologies to identify structural variants (SV) because of the ability to sequence entire DNA molecules. In this work we performed nanopore sequencing of a tumour genome to detect several types of SV.
Descrição
Palavras-chave
Nanopore Sequencing Tumour Genome Bioinformatics Tecnologias de Análise de DNA Sequencing of DNA Doenças Genéticas