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Prevalence and risk factors of fatty liver in Portuguese adults

2020-06Journal article Restricted access
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dc.contributor.authorLeitão, Jorge
dc.contributor.authorCarvalhana, Sofia
dc.contributor.authorCochicho, Joana
dc.contributor.authorSilva, Ana Paula
dc.contributor.authorVelasco, Francisco
dc.contributor.authorMedeiros, Isabel
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorBourbon, Mafalda
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorRodrigues, Vitor
dc.contributor.authorSousa, Rita
dc.contributor.authorSampaio, Filipa
dc.contributor.authorCarvalho, Armando
dc.contributor.authorCortez‐Pinto, Helena
dc.date.accessioned2021-03-06T15:47:51Z
dc.date.available2021-03-06T15:47:51Z
dc.date.issued2020-06
dc.description.abstractBackground: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly selected in 834 Portuguese adults (18-79 years). Participants were evaluated after 12-hour fasting. Anthropometric data, past history including alcohol consumption, and associated diseases were registered. Blood samples were collected for biochemical testing. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire. Presence of FL was evaluated using ultrasound, and NAFLD was diagnosed after exclusion of other causes for liver disease. Results: Adjusted prevalence of FL and NAFLD was 37.8% and 17.0%, respectively. FL individuals were older, more frequently males, with increased probability of having obesity, diabetes or harmful alcohol consumption (HAC). NAFLD individuals were also older, but had a similar sex distribution and an increased probability of obesity and diabetes. In both groups, no differences were found regarding dietary pattern or physical activity. During the same time period, nonalcoholic steatohepatitis (NASH) liver-related deaths in Portugal were 0.105/100 000, while alcohol-related liver disease mortality was 6.790/100 000. Conclusion: The large spectrum of FL was present in more than one third of the population, although only less than half could be classified as NAFLD. Other significant risk factors, such as HAC, are probably implicated in FL, explaining the low NASH-related mortality compared with the high alcohol-related mortality during the same time period.pt_PT
dc.description.sponsorshipThe present study received grants from: Portuguese Association for the Study of the Liver (APEF), Gilead Foundation and Gilead Genesis and Roche supplied laboratorial kits. APEF, Gilead Foundation and Gilead Genesis and Roche had no role in the design, analysis or writing of this article, and in the decision to submit the article for publication.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Clin Invest. 2020 Jun;50(6):e13235. doi: 10.1111/eci.13235. Epub 2020 May 19pt_PT
dc.identifier.doi10.1111/eci.13235pt_PT
dc.identifier.issn0014-2972
dc.identifier.urihttp://hdl.handle.net/10400.18/7346
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley/ Stichting European Society for Clinical Investigation Journal Foundationpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13235pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAlcohol Consumptionpt_PT
dc.subjectDiabetespt_PT
dc.subjectFatty Liverpt_PT
dc.subjectMortalitypt_PT
dc.subjectNonalcoholic Fatty Liverpt_PT
dc.subjectNutritional Patternpt_PT
dc.subjectObesitypt_PT
dc.subjectDoenças Cardio e Cérebro-vascularespt_PT
dc.subjectPortugalpt_PT
dc.titlePrevalence and risk factors of fatty liver in Portuguese adultspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPagee13235pt_PT
oaire.citation.titleEuropean Journal of Clinical Investigationpt_PT
oaire.citation.volume50pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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